Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

Chloe D. Goldsmith; Quan V. Vuong; Elham Sadeqzadeh; Costas E. Stathopoulos; Paul D. Roach; Christopher J. Scarlett

doi:10.3390/molecules200712992

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Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

Journal article

Open access

Peer reviewed

Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

Chloe D. Goldsmith, Quan V. Vuong, Elham Sadeqzadeh, Costas E. Stathopoulos, Paul D. Roach and Christopher J. Scarlett

Molecules (Basel, Switzerland), Vol.20(7), pp.12992-13004

2015

DOI: https://doi.org/10.3390/molecules200712992

PMID: 26193251

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Abstract

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 mu g/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 mu g/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.

Details

Title: Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells
Authors/Creators: Chloe D. Goldsmith - Supreme Council Of Health
Quan V. Vuong - University of Newcastle Australia
Elham Sadeqzadeh - Supreme Council Of Health
Costas E. Stathopoulos - Ghent University Global Campus
Paul D. Roach - University of Newcastle Australia
Christopher J. Scarlett - University of Newcastle Australia
Publication Details: Molecules (Basel, Switzerland), Vol.20(7), pp.12992-13004
Publisher: MDPI
Number of pages: 13
Grant note: Hunter Cancer Research Alliance (HCRA) University of Newcastle ES2012/0104 / Ramaciotti Foundation
Identifiers: 991005705536107891
Murdoch Affiliation: Food Futures Institute
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.68 Lipids; 1.68.621 Virgin Olive Oil
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
ESI research areas: Chemistry