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Journal article
Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease
Journal of Alzheimer's disease, Vol.92(2), pp.615-628
2023
PMID: 36776057
Abstract
Background:
Astrocyte reactivity is an early event along the Alzheimer’s disease (AD) continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity, is elevated across the AD continuum from preclinical to dementia stages. Monoamine oxidase-B (MAO-B) is also elevated in reactive astrocytes observed using 18F-SMBT-1 PET in AD.
Objective:
The objective of this study was to evaluate the association between the abovementioned astrocyte reactivity biomarkers.
Methods:
Plasma GFAP and Aβ were measured using the Simoa® platform in participants who underwent brain 18F-SMBT-1 and Aβ–PET imaging, comprising 54 healthy control (13 Aβ–PET+ and 41 Aβ–PET–), 11 mild cognitively impaired (3 Aβ–PET+ and 8 Aβ–PET–) and 6 probable AD (5 Aβ–PET+ and 1 Aβ–PET–) individuals. Linear regressions were used to assess associations of interest.
Results:
Plasma GFAP was associated with 18F-SMBT-1 signal in brain regions prone to early Aβ deposition in AD, such as the supramarginal gyrus (SG), posterior cingulate (PC), lateral temporal (LT) and lateral occipital cortex (LO). After adjusting for age, sex, APOE ɛ4 genotype, and soluble Aβ (plasma Aβ42/40 ratio), plasma GFAP was associated with 18F-SMBT-1 signal in the SG, PC, LT, LO, and superior parietal cortex (SP). On adjusting for age, sex, APOE ɛ4 genotype and insoluble Aβ (Aβ–PET), plasma GFAP was associated with 18F-SMBT-1 signal in the SG.
Conclusion:
There is an association between plasma GFAP and regional 18F-SMBT-1 PET, and this association appears to be dependent on brain Aβ load.
Details
- Title
- Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease
- Authors/Creators
- Pratishtha Chatterjee - School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AustraliaVincent Doré - Australian e-Health Research CentreSteve Pedrini - Edith Cowan UniversityNatasha Krishnadas - Austin HealthRohith Thota - Macquarie UniversityPierrick Bourgeat - Health and Biosecurity Flagship, Australian eHealth Research Centre, Herston, QLD, AustraliaMilos D Ikonomovic - University of PittsburghStephanie R Rainey-Smith - Murdoch University, Centre for Healthy AgeingSamantha C Burnham - Australian e-Health Research CentreChristopher Fowler - The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, AustraliaKevin Taddei - Edith Cowan UniversityRachel Mulligan - Austin HealthDavid Ames - The University of MelbourneColin L Masters - Florey Institute of Neuroscience and Mental HealthJürgen Fripp - Australian e-Health Research CentreChristopher C Rowe - Austin HealthRalph N Martins - Macquarie UniversityVictor L Villemagne - Austin HealthThe AIBL Research Group
- Publication Details
- Journal of Alzheimer's disease, Vol.92(2), pp.615-628
- Publisher
- IOS Press
- Identifiers
- 991005567367307891
- Copyright
- © 2023 – The authors.
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior