Plasma amyloid-beta levels in a pre-symptomatic Dutch-type hereditary cerebral amyloid angiopathy pedigree: A cross-sectional and longitudinal investigation

P. Chatterjee; M. Tegg; S. Pedrini; A. Fagan; C. Xiong; A. Singh; K. Taddei; S. Gardener; C. Masters; P. Schofield; G. Multhaup; T. Benzinger; J. Morris; R. Bateman; S. Greenberg; M. van Buchem; E. Stoops; H. Vanderstichele; C. Teunissen; G. Hankey; M. Wermer; H. Sohrabi; R.N. Martins; the Dominantly Inherited Alzheimer Network

doi:10.3390/ijms22062931

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Plasma amyloid-beta levels in a pre-symptomatic Dutch-type hereditary cerebral amyloid angiopathy pedigree: A cross-sectional and longitudinal investigation

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Plasma amyloid-beta levels in a pre-symptomatic Dutch-type hereditary cerebral amyloid angiopathy pedigree: A cross-sectional and longitudinal investigation

P. Chatterjee, M. Tegg, S. Pedrini, A. Fagan, C. Xiong, A. Singh, K. Taddei, S. Gardener, C. Masters, P. Schofield, …

International Journal of Molecular Sciences, Vol.22(6), Article 2931

2021

DOI: https://doi.org/10.3390/ijms22062931

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Abstract

Plasma amyloid-beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre-symptomatic Dutch-type hereditary CAA (D-CAA) mutation-carriers (MC) and non-carriers (NC) using two Aβ measurement platforms. Seventeen pre-symptomatic members of a D-CAA pedigree were assembled and followed up 3–4 years later (NC = 8; MC = 9). Plasma Aβ1-40 and Aβ1-42 were cross-sectionally and longitudinally analysed at baseline (T1) and follow-up (T2) and were found to be lower in MCs compared to NCs, cross-sectionally after adjusting for covariates, at both T1(Aβ1-40: p = 0.001; Aβ1-42: p = 0.0004) and T2 (Aβ1-40: p = 0.001; Aβ1-42: p = 0.016) employing the Single Molecule Array (Simoa) platform, however no significant differences were observed using the xMAP platform. Further, pairwise longitudinal analyses of plasma Aβ1-40 revealed decreased levels in MCs using data from the Simoa platform (p = 0.041) and pairwise longitudinal analyses of plasma Aβ1-42 revealed decreased levels in MCs using data from the xMAP platform (p = 0.041). Findings from the Simoa platform suggest that plasma Aβ may add value to a panel of biomarkers for the diagnosis of pre-symptomatic CAA, however, further validation studies in larger sample sets are required.

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Title: Plasma amyloid-beta levels in a pre-symptomatic Dutch-type hereditary cerebral amyloid angiopathy pedigree: A cross-sectional and longitudinal investigation
Authors/Creators: P. Chatterjee (Author/Creator) - Macquarie University
M. Tegg (Author/Creator) - Edith Cowan University
S. Pedrini (Author/Creator) - Edith Cowan University
A. Fagan (Author/Creator) - Washington University in St. Louis
C. Xiong (Author/Creator) - Washington University in St. Louis
A. Singh (Author/Creator) - Macquarie University
K. Taddei (Author/Creator) - Edith Cowan University
S. Gardener (Author/Creator) - Edith Cowan University
C. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental Health
P. Schofield (Author/Creator) - Neuroscience Research Australia
G. Multhaup (Author/Creator) - McGill University
T. Benzinger (Author/Creator)
J. Morris (Author/Creator) - Washington University in St. Louis
R. Bateman (Author/Creator) - Washington University in St. Louis
S. Greenberg (Author/Creator) - Massachusetts General Hospital
M. van Buchem (Author/Creator) - Leiden University Medical Center
E. Stoops (Author/Creator) - ADx NeuroSciences, 9052 Gent, Belgium.
H. Vanderstichele (Author/Creator) - Biomarkable, 9000 Gent, Belgium.
C. Teunissen (Author/Creator) - Amsterdam Neuroscience
G. Hankey (Author/Creator) - The University of Western Australia
M. Wermer (Author/Creator)
H. Sohrabi (Author/Creator) - Macquarie University
R.N. Martins (Author/Creator) - Macquarie University
the Dominantly Inherited Alzheimer Network (Author/Creator)
Publication Details: International Journal of Molecular Sciences, Vol.22(6), Article 2931
Publisher: MDPI
Identifiers: 991005542635807891
Copyright: © 2021 by the authors
Murdoch Affiliation: College of Science, Health, Engineering and Education; Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
ESI research areas: Chemistry