Plasma concentrations of endothelin-like immunoreactivity in healthy horses and horses with naturally acquired gastrointestinal tract disorders

Chidambaram M Ramaswamy; Susan C Eades; Changaram S Venugopal; Giselle L Hosgood; Frank Garza; Steven A Barker; Rustin M Moore

doi:10.2460/ajvr.2002.63.454

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Plasma concentrations of endothelin-like immunoreactivity in healthy horses and horses with naturally acquired gastrointestinal tract disorders

Journal article

Open access

Peer reviewed

Plasma concentrations of endothelin-like immunoreactivity in healthy horses and horses with naturally acquired gastrointestinal tract disorders

Chidambaram M Ramaswamy, Susan C Eades, Changaram S Venugopal, Giselle L Hosgood, Frank Garza, Steven A Barker and Rustin M Moore

American journal of veterinary research, Vol.63(3), pp.454-458

2002

DOI: https://doi.org/10.2460/ajvr.2002.63.454

PMID: 11911584

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Abstract

Objective To compare plasma endothelin (ET)- like immunoreactivity between healthy horses and those with naturally acquired gastrointestinal tract disorders. Animals 29 healthy horses and 142 horses with gastrointestinal tract disorders. Procedure Blood samples were collected from healthy horses and from horses with gastrointestinal tract disorders prior to treatment. Magnitude and duration of abnormal clinical signs were recorded, and clinical variables were assessed via thorough physical examinations. Plasma concentrations of ET-like immunoreactivity were measured by use of a radioimmunoassay for human endothelin-1, and CBC and plasma biochemical analyses were performed. Results Plasma ET-like immunoreactivity concentration was significantly increased in horses with gastrointestinal tract disorders, compared with healthy horses. Median plasma concentration of ET-like immunoreactivity was 1.80 pg/ml (range, 1.09 to 3.2 pg/ml) in healthy horses. Plasma ET-like immunoreactivity was greatest in horses with strangulating largeintestinal obstruction (median, 10.02 pg/ml; range, 3.8 to 22.62 pg/ml), peritonitis (9.19 pg/ml; 7.89 to 25.83 pg/ml), and enterocolitis (8.89 pg/ml; 6.30 to 18.36 pg/ml). Concentration of ET-like immunoreactivity was significantly associated with survival, PCV, and duration of signs of pain. However, correlations for associations with PCV and duration of pain were low. Conclusions and Clinical Relevance Horses with gastrointestinal tract disorders have increased plasma concentrations of ET-like immunoreactivity, compared with healthy horses. The greatest values were detected in horses with large-intestinal strangulating obstructions, peritonitis, and enterocolitis. This suggests a potential involvement of ET in the pathogenesis of certain gastrointestinal tract disorders in horses.

Details

Title: Plasma concentrations of endothelin-like immunoreactivity in healthy horses and horses with naturally acquired gastrointestinal tract disorders
Authors/Creators: Chidambaram M Ramaswamy - Louisiana State University
Susan C Eades
Changaram S Venugopal
Giselle L Hosgood
Frank Garza
Steven A Barker
Rustin M Moore
Publication Details: American journal of veterinary research, Vol.63(3), pp.454-458
Identifiers: 991005592761507891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.127 Molecular & Cell Biology - Pharmacology; 1.127.1303 Endothelin
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science