Journal article
Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume
Journal of Neurochemistry, Vol.163(1), pp.53-67
2022
Abstract
Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that high levels could be detrimental, but this effect is likely attributed to Low-Density Lipoprotein (LDL) cholesterol. On the other hand, High-Density Lipoproteins (HDL) cholesterol levels have been associated with reduced brain amyloidosis and improved cognitive function. However, recent findings have suggested that HDL-functionality, which depends upon the HDL-cargo proteins associated with HDL, rather than HDL levels, appears to be the key factor, suggesting a quality over quantity status. In this report, we have assessed the HDL-cargo (Cholesterol, ApoA-I, ApoA-II, ApoC-I, ApoC-III, ApoD, ApoE, ApoH, ApoJ, CRP, and SAA) in stable healthy control (HC), healthy controls who will convert to MCI/AD (HC-Conv) and AD patients (AD). Compared to HC we observed an increased cholesterol/ApoA-I ratio in AD and HC-Conv, as well as an increased ApoD/ApoA-I ratio and a decreased ApoA-II/ApoA-I ratio in AD. Higher cholesterol/ApoA-I ratio was also associated with lower cortical grey matter volume and higher ventricular volume, while higher ApoA-II/ApoA-I and ApoJ/ApoA-I ratios were associated with greater cortical grey matter volume (and for ApoA-II also with greater hippocampal volume) and smaller ventricular volume. Additionally, in a clinical status-independent manner, the ApoE/ApoA-I ratio was significantly lower in APOE ε4 carriers and lowest in APOE ε4 homozygous. Together, these data indicate that in AD patients the composition of HDL is altered, which may affect HDL functionality, and such changes are associated with altered regional brain volumetric data.
Details
- Title
- Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume
- Authors/Creators
- S. Pedrini (Author/Creator) - Edith Cowan UniversityJ.D. Doecke (Author/Creator) - Australian e-Health Research CentreE. Hone (Author/Creator) - Edith Cowan UniversityP. Wang (Author/Creator) - Murdoch UniversityR. Thota (Author/Creator) - Macquarie UniversityA.I. Bush (Author/Creator)C.C. Rowe (Author/Creator) - Austin HealthV. Doré (Author/Creator) - Austin HealthV.L. Villemagne (Author/Creator) - University of PittsburghD. Ames (Author/Creator) - National Ageing Research InstituteS. Rainey‐Smith (Author/Creator) - Edith Cowan UniversityG. Verdile (Author/Creator) - Curtin UniversityH.R. Sohrabi (Author/Creator) - Murdoch UniversityM.R. Raida (Author/Creator) - National University of SingaporeK. Taddei (Author/Creator) - Edith Cowan UniversityS. Gandy (Author/Creator) - Icahn School of Medicine at Mount SinaiC.L. Masters (Author/Creator) - Cooperative Research Centre for Mental HealthP. Chatterjee (Author/Creator) - Macquarie UniversityR.N. Martins (Author/Creator) - Edith Cowan University
- Publication Details
- Journal of Neurochemistry, Vol.163(1), pp.53-67
- Publisher
- John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
- Identifiers
- 991005540967807891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
11 File views/ downloads
76 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.57 Alzheimer's Mechanisms
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior