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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Plasma lipid profiles change with increasing numbers of mild traumatic brain injuries in rats
Metabolites, Vol.12(4), Article 322
2022
Abstract
Mild traumatic brain injury (mTBI) causes structural, cellular and biochemical alterations which are difficult to detect in the brain and may persist chronically following single or repeated injury. Lipids are abundant in the brain and readily cross the blood-brain barrier, suggesting that lipidomic analysis of blood samples may provide valuable insight into the neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) to examine plasma lipid concentrations at 11 days following sham (no injury), one (1×) or two (2×) mTBI in rats. Eighteen lipid species were identified that distinguished between sham, 1× and 2× mTBI. Three distinct patterns were found: (1) lipids that were altered significantly in concentration after either 1× or 2× F mTBI: cholesterol ester CE (14:0) (increased), phosphoserine PS (14:0/18:2) and hexosylceramide HCER (d18:0/26:0) (decreased), phosphoinositol PI(16:0/18:2) (increased with 1×, decreased with 2× mTBI); (2) lipids that were altered in response to 1× mTBI only: free fatty acid FFA (18:3 and 20:3) (increased); (3) lipids that were altered in response to 2× mTBI only: HCER (22:0), phosphoethanolamine PE (P-18:1/20:4 and P-18:0/20:1) (increased), lysophosphatidylethanolamine LPE (20:1), phosphocholine PC (20:0/22:4), PI (18:1/18:2 and 20:0/18:2) (decreased). These findings suggest that increasing numbers of mTBI induce a range of changes dependent upon the lipid species, which likely reflect a balance of damage and reparative responses.
Details
- Title
- Plasma lipid profiles change with increasing numbers of mild traumatic brain injuries in rats
- Authors/Creators
- C.C. Anyaegbu (Author/Creator)H. Szemray (Author/Creator)S.C. Hellewell (Author/Creator)N.G. Lawler (Author/Creator)K. Leggett (Author/Creator)C. Bartlett (Author/Creator)B. Lins (Author/Creator)T. McGonigle (Author/Creator)M. Papini (Author/Creator)R.S. Anderton (Author/Creator)L. Whiley (Author/Creator)M. Fitzgerald (Author/Creator)
- Publication Details
- Metabolites, Vol.12(4), Article 322
- Publisher
- MDPI
- Identifiers
- 991005541985707891
- Copyright
- © 2022 by the authors
- Murdoch Affiliation
- Centre for Computational and Systems Medicine; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.134 Trauma & Emergency Surgery
- 1.134.286 Traumatic Brain Injury
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Biology & Biochemistry