Plasma lipoprotein subclass variation in middle-aged and older adults: Sex-stratified distributions and associations with health status and cardiometabolic risk factors

Reika Masuda; Julien Wist; Sam L Lodge; Torben Kimhofer; Michael Hunter; Jennie Hui; John P. Beilby; John R. Burnett; Girish Dwivedi; Markus P. Schlaich; Sze-How Bong; Ruey Leng Leng Loo; Elaine Holmes; Jeremy K Nicholson; Bu B Yeap

doi:10.1016/j.jacl.2023.06.004

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Plasma lipoprotein subclass variation in middle-aged and older adults: Sex-stratified distributions and associations with health status and cardiometabolic risk factors

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Plasma lipoprotein subclass variation in middle-aged and older adults: Sex-stratified distributions and associations with health status and cardiometabolic risk factors

Reika Masuda, Julien Wist, Sam L Lodge, Torben Kimhofer, Michael Hunter, Jennie Hui, John P. Beilby, John R. Burnett, Girish Dwivedi, Markus P. Schlaich, …

Journal of clinical lipidology, Vol.17(5), pp.677-687

2023

DOI: https://doi.org/10.1016/j.jacl.2023.06.004

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Abstract

Apolipoproteins

Cardiovascular disease

Cholesterol

Diabetes

Lipoproteins

Nuclear magnetic resonance spectroscopy

Triglycerides

BACKGROUND Circulating lipids and lipoproteins mediate cardiovascular risk, however routine plasma lipid biochemistry provides limited information on pro-atherogenic remnant particles. OBJECTIVE We analysed plasma lipoprotein subclasses including very low-density and intermediate-density lipoprotein (VLDL and IDL); and assessed their associations with health and cardiometabolic risk. METHODS From 1,976 community-dwelling adults aged 45–67 years, 114/1071 women (10.6%) and 153/905 men (16.9%) were categorised as very healthy. Fasting plasma lipoprotein profiles comprising 112 parameters were measured using 1H nuclear magnetic resonance (NMR) spectroscopy, and associations with health status and cardiometabolic risk factors examined. RESULTS HDL cholesterol was higher, and IDL and VLDL cholesterol and triglycerides lower, in very healthy women compared to other women, and women compared to men. IDL and VLDL cholesterol and triglyceride were lower in very healthy men compared to other men. HDL cholesterol and apolipoprotein (apo) A-I were inversely, and IDL and VLDL cholesterol, apoB-100, and apoB-100/apoA-I ratio directly associated with body mass index (BMI) in women and men. In women, LDL, IDL and VLDL cholesterol increased with age. Women with diabetes and cardiovascular disease had higher cholesterol, triglycerides, phospholipids and free cholesterol across IDL and VLDL fractions, with similar trends for men with diabetes. CONCLUSION Lipoprotein subclasses and density fractions, and their lipid and apolipoprotein constituents, are differentially distributed by sex, health status and BMI. Very healthy women and men are distinguished by favourable lipoprotein profiles, particularly lower concentrations of VLDL and IDL, providing reference intervals for comparison with general populations and adults with cardiometabolic risk factors.

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Title: Plasma lipoprotein subclass variation in middle-aged and older adults: Sex-stratified distributions and associations with health status and cardiometabolic risk factors
Authors/Creators: Reika Masuda - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia
Julien Wist - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia
Sam L Lodge
Torben Kimhofer - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia
Michael Hunter - School of Population and Global Health, University of Western Australia, Perth, WA, 6009, Australia
Jennie Hui - PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, WA, 6009, Australia
John P. Beilby - School of Biomedical Sciences, University of Western Australia, Perth, WA, 6009, Australia
John R. Burnett - Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital & Fiona Stanley Hospital Network, Perth, WA, 6000, Australia
Girish Dwivedi - Medical School, University of Western Australia, Perth, WA, 6009, Australia
Markus P. Schlaich - Medical School, University of Western Australia, Perth, WA, 6009, Australia
Sze-How Bong - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia
Ruey Leng Leng Loo - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia
Elaine Holmes - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia
Jeremy K Nicholson - Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia
Bu B Yeap - Medical School, University of Western Australia, Perth, WA, 6009, Australia
Publication Details: Journal of clinical lipidology, Vol.17(5), pp.677-687
Publisher: Elsevier Inc
Identifiers: 991005592169607891
Murdoch Affiliation: Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

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