Journal article
Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.14(1), Art. e12307
2022
Abstract
Introduction
We evaluated a new Simoa plasma assay for phosphorylated tau (P-tau) at aa217 enhanced by additional p-tau sites (p217+tau).
Methods
Plasma p217+tau levels were compared to 18F-NAV4694 amyloid beta (Aβ) positron emission tomography (PET) and 18F-MK6240 tau PET in 174 cognitively impaired (CI) and 223 cognitively unimpaired (CU) participants.
Results
Compared to Aβ− CU, the plasma levels of p217+tau increased 2-fold in Aβ+ CU and 3.5-fold in Aβ+ CI. In Aβ− the p217+tau levels did not differ significantly between CU and CI. P217+tau correlated with Aβ centiloids P = .67 (CI, P = .64; CU, P = .45) and tau SUVRMT P = .63 (CI, P = .69; CU, P = .34). Area under curve (AUC) for Alzheimer's disease (AD) dementia versus Aβ− CU was 0.94, for AD dementia versus other dementia was 0.93, for Aβ+ versus Aβ− PET was 0.89, and for tau+ versus tau− PET was 0.89.
Discussion
Plasma p217+tau levels elevate early in the AD continuum and correlate well with Aβ and tau PET.
Details
- Title
- Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum
- Authors/Creators
- V. Doré (Author/Creator) - Austin HealthJ.D. Doecke (Author/Creator) - Australian e-Health Research CentreZ.S. Saad (Author/Creator) - Neuroscience Biomarkers Janssen Research and Development La Jolla California USA.G. Triana‐Baltzer (Author/Creator)R. Slemmon (Author/Creator) - Neuroscience Biomarkers Janssen Research and Development La Jolla California USA.N. Krishnadas (Author/Creator) - Austin HealthP. Bourgeat (Author/Creator) - Australian e-Health Research CentreK. Huang (Author/Creator) - Austin HealthS. Burnham (Author/Creator) - Australian e-Health Research CentreC. Fowler (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS.R. Rainey‐Smith (Author/Creator)A.I. Bush (Author/Creator) - Florey Institute of Neuroscience and Mental HealthL. Ward (Author/Creator) - Florey Institute of Neuroscience and Mental HealthJ. Robertson (Author/Creator) - Florey Institute of Neuroscience and Mental HealthR.N. Martins (Author/Creator) - Edith Cowan UniversityC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthV.L. Villemagne (Author/Creator) - Austin HealthJ. Fripp (Author/Creator) - Australian e-Health Research CentreH.C. Kolb (Author/Creator) - Neuroscience Biomarkers Janssen Research and Development La Jolla California USA.C.C. Rowe (Author/Creator) - Austin Health
- Publication Details
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.14(1), Art. e12307
- Publisher
- Wiley Periodicals, LLC on behalf of Alzheimer's Association
- Identifiers
- 991005540585807891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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