Files and links (1)
CC BY-NC-ND V4.0, Open Access
Journal article
Plugging the leaks: Antibiotic resistance at human–animal interfaces in low‐resource settings
Frontiers in ecology and the environment, Early View
2023
Abstract
Antibiotic resistance is one of the greatest public health challenges of our time. International efforts to curb resistance have largely focused on drug development and limiting unnecessary antibiotic use. However, in areas where water, sanitation, and hygiene infrastructure is lacking, we propose that bacterial flow between humans and animals can exacerbate the emergence and spread of resistant pathogens. Here, we describe the consequences of poor environmental controls by comparing mobile resistance elements among Escherichia coli recovered from humans and meat in Cambodia, a middle‐income country with substantial human–animal connectivity and unregulated antibiotic use. We identified identical mobile resistance elements and a conserved transposon region that were widely dispersed in both humans and animals, a phenomenon rarely observed in high‐income settings. Our findings indicate that plugging leaks at human–animal interfaces should be a critical part of addressing antibiotic resistance in low‐ and especially middle‐income countries.
Details
- Title
- Plugging the leaks: Antibiotic resistance at human–animal interfaces in low‐resource settings
- Authors/Creators
- Maya L Nadimpalli - Georgia Department of Public HealthMarc Stegger - Department of Bacteria, Parasites and Fungi Statens Serum Institut Copenhagen Denmark, Department of Environmental and Occupational Health, Milken Institute School of Public Health The George Washington University Washington DC, Antimicrobial Resistance and Infectious Diseases Laboratory, Harry Butler Institute Murdoch University Perth AustraliaRoberto Viau - Tufts UniversityVuthy Yith - Institut PasteurAgathe de Lauzanne - Institut Pasteur du CambodgeNita Sem - Institut Pasteur du CambodgeLaurence Borand - Institut Pasteur du CambodgeBich‐tram Huynh - InsermSylvain Brisse - Université Paris CitéVirginie Passet - Université Paris CitéSøren Overballe-Petersen - Statens Serum InstitutMaliha Aziz - Milken InstituteMalika Gouali - Institut Pasteur du CambodgeJan Jacobs - Instituut voor Tropische GeneeskundeThong Phe - Sihanouk Hospital Center of HOPEBruce A Hungate - Northern Arizona UniversityVictor O Leshyk - Northern Arizona UniversityAmy J Pickering - Tufts UniversityFrançois Gravey - Université de Caen NormandieCindy M Liu - Milken InstituteTimothy J Johnson - University of MinnesotaSimon Le Hello - Institut PasteurLance B Price - Milken Institute
- Publication Details
- Frontiers in ecology and the environment, Early View
- Publisher
- Wiley Periodicals LLC on behalf of The Ecological Society of America
- Identifiers
- 991005606967607891
- Copyright
- © 2023 The Authors
- Murdoch Affiliation
- Harry Butler Institute
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
2 File views/ downloads
15 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.146 Antimicrobial Resistance
- Web Of Science research areas
- Ecology
- Environmental Sciences
- ESI research areas
- Environment/Ecology