Journal article
Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia
Journal of Antimicrobial Chemotherapy, Vol.72(4), pp.998-1001
2017
Abstract
Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.
Details
- Title
- Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia
- Authors/Creators
- S.J. van Hal (Author/Creator)B.A. Espedido (Author/Creator)G.W. Coombs (Author/Creator)B.P. Howden (Author/Creator)T.M. Korman (Author/Creator)G.R. Nimmo (Author/Creator)I.B. Gosbell (Author/Creator)S.O. Jensen (Author/Creator)
- Publication Details
- Journal of Antimicrobial Chemotherapy, Vol.72(4), pp.998-1001
- Publisher
- Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
- Identifiers
- 991005543645407891
- Copyright
- © The Author 2016
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology