Polycystic kidney disease in Bull Terriers: an autosomal dominant inherited disorder

C.A. O'Leary; B.M. Mackay; R. Malik; J.E. Edmondston; W.F. Robinson; C.R. Huxtable

doi:10.1111/j.1751-0813.1999.tb10304.x

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Polycystic kidney disease in Bull Terriers: an autosomal dominant inherited disorder

Journal article

Peer reviewed

Polycystic kidney disease in Bull Terriers: an autosomal dominant inherited disorder

C.A. O'Leary, B.M. Mackay, R. Malik, J.E. Edmondston, W.F. Robinson and C.R. Huxtable

Australian Veterinary Journal, Vol.77(6), pp.361-366

1999

DOI: https://doi.org/10.1111/j.1751-0813.1999.tb10304.x

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Abstract

The prevalence, mode of inheritance and urinalysis findings in Bull Terriers with polycystic kidney disease were assessed by screening 150 clinically normal dogs. The disorder was diagnosed in 39 dogs on the basis of renal ultrasound results and family history of the disease. In equivocal cases confirmation required gross and histopathological renal examination. Necropsy was performed on nine affected dogs and the kidneys from another five affected animals were also examined. Renal cysts were usually bilateral, occurred in cortex and medulla and varied from less than 1 mm to over 2.5 cm in diameter. Cysts were lined by epithelial cells of nephron origin. Abnormal urine sediment and proteinuria were common in affected dogs. The disease appears to be inherited in a highly penetrant autosomal dominant manner.

Details

Title: Polycystic kidney disease in Bull Terriers: an autosomal dominant inherited disorder
Authors/Creators: C.A. O'Leary (Author/Creator) - Murdoch University
B.M. Mackay (Author/Creator) - Manly Hospital
R. Malik (Author/Creator) - The University of Sydney
J.E. Edmondston (Author/Creator) - Murdoch University
W.F. Robinson (Author/Creator) - The University of Queensland
C.R. Huxtable (Author/Creator) - Murdoch University
Publication Details: Australian Veterinary Journal, Vol.77(6), pp.361-366
Publisher: Wiley-Blackwell
Identifiers: 991005544047307891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.108 Molecular & Cell Biology - Cancer & Development; 1.108.1327 Ciliopathies
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science