Journal article
Polygenic control of Human T Lymphotropic Virus Type I (HTLV‐I) Provirus Load and the risk of HTLV‐I–Associated Myelopathy/Tropical Spastic Paraparesis
The Journal of Infectious Diseases, Vol.186(7), pp.932-939
2002
Abstract
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is one outcome of infection with HTLV-I. A population association study of 229 patients with HAM/TSP and 202 healthy carriers of HTLV-I in southern Japan showed that this outcome of HTLV-I infection and the HTLV-I provirus load are under polygenic control. Of 58 polymorphic sites studied in 39 non-HLA candidate gene loci, 3 new host genetic factors that influenced the risk of HAM/TSP or the provirus load of HTLV-I were identified. The promoter TNF-863A allele predisposed to HAM/TSP, whereas SDF-1 +801A 3′UTR, and IL-15 191 C alleles conferred protection. Knowledge of HTLV-I-infected individuals' ages, sex, provirus load, HTLV-I subgroup, and genotypes at the loci HLA-A, HLA-C, SDF-1, and TNF-α allowed for the correct identification of 88% of cases of HAM/TSP in this Japanese cohort.
Details
- Title
- Polygenic control of Human T Lymphotropic Virus Type I (HTLV‐I) Provirus Load and the risk of HTLV‐I–Associated Myelopathy/Tropical Spastic Paraparesis
- Authors/Creators
- A.M. Vine (Author/Creator)A.D. Witkover (Author/Creator)A.L. Lloyd (Author/Creator)K.J.M. Jeffery (Author/Creator)A. Siddiqui (Author/Creator)S.E.F. Marshall (Author/Creator)M. Bunce (Author/Creator)N. Eiraku (Author/Creator)S. Izumo (Author/Creator)K. Usuku (Author/Creator)M. Osame (Author/Creator)C.R.M. Bangham (Author/Creator)
- Publication Details
- The Journal of Infectious Diseases, Vol.186(7), pp.932-939
- Publisher
- Oxford University Press
- Identifiers
- 991005543500607891
- Copyright
- © 2002 the Infectious Diseases Society of America
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1464 HTLV-1/BLV Pathogenesis
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
- ESI research areas
- Immunology