Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome

M.R. Jones; S.G. Wilson; B.H. Mullin; R. Mead; F. Dudbridge; G.F. Watts; B.G.A. Stuckey

doi:10.1016/j.fertnstert.2007.10.079

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Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome

Journal article

Peer reviewed

Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome

M.R. Jones, S.G. Wilson, B.H. Mullin, R. Mead, F. Dudbridge, G.F. Watts and B.G.A. Stuckey

Fertility and Sterility, Vol.90(6), pp.2298-2303

2008

DOI: https://doi.org/10.1016/j.fertnstert.2007.10.079

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Abstract

Objective: To investigate polymorphisms in postinsulin receptor signaling. To investigate PIK3R1, SLC2A4, SLC2A4RG, and MEF2A to determine whether these genes are associated with susceptibility to polycystic ovary syndrome (PCOS) or key phenotypic features of insulin resistance in subjects with PCOS. Design: Case-control study. Setting: Participants with PCOS were recruited from a clinical practice database, and controls from the general community. Patient(s): One hundred seventy-three patients with PCOS conforming to the National Institutes of Health (NIH) diagnostic criteria, all of Caucasian descent; 107 normally ovulating women of white descent from the general community. Intervention(s): Drawing of blood for DNA extraction. Main Outcome Measure(s): Frequency of PIK3R1, SLC2A4, SLC2A4RG, and MEF2A polymorphisms in case and control subjects. Result(s): No significant difference between the frequency of the polymorphisms in case and control women was identified. No single nucleotide polymorphism studied in any of these four genes was associated with the PCOS phenotype. Conclusion(s): Polymorphisms in the PIK3R1, SLC2A4, SLC2A4RG, and MEF2A genes are not associated with key PCOS phenotypes.

Details

Title: Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome
Authors/Creators: M.R. Jones (Author/Creator) - Sir Charles Gairdner Hospital
S.G. Wilson (Author/Creator) - The University of Western Australia
B.H. Mullin (Author/Creator) - Sir Charles Gairdner Hospital
R. Mead (Author/Creator) - Murdoch University
F. Dudbridge (Author/Creator) - MRC Biostatistics Unit
G.F. Watts (Author/Creator) - The University of Western Australia
B.G.A. Stuckey (Author/Creator) - Keogh Institute for Medical Research
Publication Details: Fertility and Sterility, Vol.90(6), pp.2298-2303
Publisher: Elsevier
Identifiers: 991005541374207891
Copyright: © 2008 American Society for Reproductive Medicine.
Murdoch Affiliation: School of Biological Sciences and Biotechnology
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.81 Reproductive Biology; 1.81.510 PCOS and Infertility
Web Of Science research areas: Obstetrics & Gynecology; Reproductive Biology
ESI research areas: Clinical Medicine