Journal article
Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients
Journal of NeuroVirology, Vol.22(4), pp.508-517
2016
Abstract
HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV+ black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p < 0.0001; R 2 = 0.19) or haplotypes (model p < 0.0001; R 2 = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study.
Details
- Title
- Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients
- Authors/Creators
- H. Goullee (Author/Creator)A.L. Wadley (Author/Creator)C.L. Cherry (Author/Creator)R.J.N. Allcock (Author/Creator)M. Black (Author/Creator)P.R. Kamerman (Author/Creator)P. Price (Author/Creator)
- Publication Details
- Journal of NeuroVirology, Vol.22(4), pp.508-517
- Publisher
- Springer US
- Identifiers
- 991005543492307891
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
41 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1615 HIV Neurocognitive Disorders
- Web Of Science research areas
- Neurosciences
- Virology
- ESI research areas
- Neuroscience & Behavior