Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder

T. Traks; K. Koido; T. Eller; E. Maron; K. Kingo; V. Vasar; E. Vasar; S. Kõks

doi:10.1186/1471-2350-9-111

Back

Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder

Journal article

Open access

Peer reviewed

Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder

T. Traks, K. Koido, T. Eller, E. Maron, K. Kingo, V. Vasar, E. Vasar and S. Kõks

BMC Medical Genetics, Vol.9(1)

2008

DOI: https://doi.org/10.1186/1471-2350-9-111

Files and links (2)

pdf

depressive disorder.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

Background Innate immune inflammatory response is suggested to have a role in the pathogenesis of major depressive disorder (MDD). Interleukin (IL)-10 family cytokines IL-10, IL-19, IL-20, and IL-24 are all implicated in the inflammatory processes and polymorphisms in respective genes have been associated with various immunopathological conditions. This study was carried out to investigate whether single-nucleotide polymorphisms (SNPs) in these genes are also associated with MDD. Methods Case-control association study was performed with seven SNPs from the IL10 gene cluster. 153 patients with MDD and 277 healthy control individuals were recruited. Results None of the selected SNPs were individually associated with MDD. The linkage disequilibrium (LD) analysis indicated the existence of two recombination sites in the IL10 gene cluster, thus confirming the formerly established LD pattern of this genomic region. This also created two haplotype blocks, both consisting of three SNPs. Additionally, the haplotype analysis detected a significantly higher frequency of block 2 (IL20 and IL24 genes) haplotype TGC in the patients group compared to healthy control individuals (P = 0.0097). Conclusion Our study established increased risk for MDD related to the IL20 and IL24 haplotype and suggests that cytokines may contribute to the pathogenesis of MDD. Since none of the block 2 SNPs were individually associated with MDD, it is possible that other polymorphisms linked to them contribute to the disease susceptibility. Future studies are needed to confirm the results and to find the possible functional explanation.

Details

Title: Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder
Authors/Creators: T. Traks (Author/Creator) - University of Tartu
K. Koido (Author/Creator) - University of Tartu
T. Eller (Author/Creator) - University of Tartu
E. Maron (Author/Creator) - University of Tartu
K. Kingo (Author/Creator) - University of Tartu
V. Vasar (Author/Creator) - University of Tartu
E. Vasar (Author/Creator) - University of Tartu
S. Kõks (Author/Creator) - University of Tartu
Publication Details: BMC Medical Genetics, Vol.9(1)
Publisher: BioMed Central
Identifiers: 991005544202107891
Copyright: © 2019 BioMed Central Ltd
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

17 File views/ downloads

32 Record Views

29 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.21 Psychiatry; 1.21.1828 Neuroinflammation
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics