Journal article
Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis
Genes & Immunity, Vol.5(2), pp.117-121
2004
Abstract
We analyzed the frequency of single-nucleotide polymorphisms (SNPs) at positions −1053 (rs 2981572), 1380 (rs 2981573), 1462 (rs 2232360), and 3978 (rs 1518108) of the human interleukin-20 (IL-20) gene by tetraprimer ARMS-PCR method. A significant association between patients with psoriasis and the G allele at position −1053 (P<0.05) was established. The pairwise linkage disequilibrium (LD) matrix showed that the nearly complete LD was present within the polymorphisms at positions −1053, 1380, and 1462 of the IL-20 gene. We found that patients with plaque psoriasis had a higher frequency of the HT3 GAA haplotype (P<0.01, OR 2.341, 95% CI: 1.346–4.074) compared to the control group. Likewise, the HT3 GAA haplotype was associated with an increased risk of early-onset psoriasis (P<0.01, OR 2.305, 95% CI: 1.285–4.132), late onset of disease (P<0.01, OR 2.542, 95% CI: 1.266–5.102), familial psoriasis (P<0.02, OR 2.220, 95% CI: 1.249–3.945), and sporadic disease (P<0.01, OR 2.523, 95% CI: 1.390–4.580). Our data indicate that IL-20 gene polymorphisms should have a role in determining susceptibility to plaque-type psoriasis. The possible role of the studied SNPs in the regulation of the expression of IL-20 is unknown yet and needs further studies.
Details
- Title
- Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis
- Authors/Creators
- K. Kingo (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuT. Nikopensius (Author/Creator) - University of TartuH. Silm (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Genes & Immunity, Vol.5(2), pp.117-121
- Publisher
- Springer Nature
- Identifiers
- 991005541835507891
- Copyright
- © 2019 Springer Nature Limited
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.487 Regulatory T Cells
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Molecular Biology & Genetics