Journal article
Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder
Brain and Behavior, Vol.5(4)
2015
Abstract
Background
The immune system has been increasingly implicated in the development of mood and anxiety disorders. Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (IKBKE) gene encodes IKKε protein that is involved in innate immunity, predominantly antiviral response generation. It also bears pro‐inflammatory properties that could affect psychiatric outcomes. In order to investigate the possible role of IKBKE gene in major depressive disorder (MDD) and panic disorder (PD), we conducted a case–control genetic association study concerning these disorders.
Methods
In all, 14 SNPs of IKBKE gene were genotyped in groups of 391 patients with MDD and 190 patients with PD together with respective 389 and 371 healthy control individuals. The given groups were further divided by gender for additional analyses.
Results
Substantial genetic associations were revealed between IKBKE SNPs and MDD (multiple testing adjusted P < 0.05) and suggestive associations in case of PD (Padj > 0.05). In addition, two SNPs that were only associated with PD among males, also displayed significantly different allele frequencies compared to PD females. This may indicate a specific role of these SNPs in male PD, but caution should be applied here due to the small size of the studied PD males group.
Conclusions
The results of this study confirm our initial findings and indicate a possible role of IKBKE gene in mood and anxiety disorders.
Details
- Title
- Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder
- Authors/Creators
- T. Traks (Author/Creator) - University of TartuK. Koido (Author/Creator) - University of TartuR. Balõtšev (Author/Creator) - University of TartuT.. Eller (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuE. Maron (Author/Creator) - Imperial College LondonI. Tõru (Author/Creator) - University of TartuJ. Shlik (Author/Creator) - University of OttawaE. Vasar (Author/Creator) - University of TartuV. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Brain and Behavior, Vol.5(4)
- Publisher
- Wiley Periodicals, Inc.
- Identifiers
- 991005545415007891
- Copyright
- © 2015 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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