Poor sleep quality and progression of gait impairment in an incident Parkinson’s disease cohort

S. O’Dowd; B. Galna; R. Morris; R.A. Lawson; C. McDonald; A.J. Yarnall; D.J. Burn; L. Rochester; K.N. Anderson

doi:10.3233/JPD-161062

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Poor sleep quality and progression of gait impairment in an incident Parkinson’s disease cohort

Journal article

Peer reviewed

Poor sleep quality and progression of gait impairment in an incident Parkinson’s disease cohort

S. O’Dowd, B. Galna, R. Morris, R.A. Lawson, C. McDonald, A.J. Yarnall, D.J. Burn, L. Rochester and K.N. Anderson

Journal of Parkinson's Disease, Vol.7(3), pp.465-470

2017

DOI: https://doi.org/10.3233/JPD-161062

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Abstract

Abnormal sleep may associate with cognitive decline in Parkinson’s disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait.

Details

Title: Poor sleep quality and progression of gait impairment in an incident Parkinson’s disease cohort
Authors/Creators: S. O’Dowd (Author/Creator)
B. Galna (Author/Creator) - Newcastle University
R. Morris (Author/Creator) - Newcastle University
R.A. Lawson (Author/Creator) - Newcastle University
C. McDonald (Author/Creator) - University of Newcastle Australia
A.J. Yarnall (Author/Creator) - Newcastle University
D.J. Burn (Author/Creator) - Newcastle University
L. Rochester (Author/Creator) - Newcastle University
K.N. Anderson (Author/Creator) - Newcastle upon Tyne Hospitals NHS Foundation Trust
Publication Details: Journal of Parkinson's Disease, Vol.7(3), pp.465-470
Publisher: IOS Press
Identifiers: 991005542943807891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.67 Parkinson's Disease
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior