Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis

C.A. Sherrington; M.W. Knuiman; M.L. Divitini; H.C. Bartholomew; D.J. Cullen; J.K. Olynyk

doi:10.1111/j.1440-1746.2006.04062.x

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Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis

Journal article

Peer reviewed

Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis

C.A. Sherrington, M.W. Knuiman, M.L. Divitini, H.C. Bartholomew, D.J. Cullen and J.K. Olynyk

Journal of Gastroenterology and Hepatology, Vol.21(3), pp.595-598

2006

DOI: https://doi.org/10.1111/j.1440-1746.2006.04062.x

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Abstract

Background and Aim: Mutations in the hemochromatosis (HFE) gene are carried by one in three individuals of British Isles descent and may result in increased iron stores. These increased iron stores could potentially induce or exacerbate diseases, such as arthritis, in which iron has a role in pathogenesis. Although arthritis is a well-known association of clinically overt hereditary hemochromatosis, controversy surrounds the role of mutations in the HFE gene as risk factors for arthritis. The aim of the present study was to determine whether mutations in the HFE gene are associated with an increased prevalence of arthritis. Methods: A population-based study was conducted in Busselton, Western Australia, of the prevalence of arthritis in 1372 individuals of British Isles descent. Participants completed a questionnaire and general physical examination. Analysis for C282Y and H63D HFE mutations was undertaken. Unadjusted and adjusted odds ratios (OR) were calculated for the relationship between HFE mutations and the prevalence of self-reported, doctor-diagnosed arthritis. Results: There was no association between the presence of HFE mutations and the prevalence of self-reported, doctor-diagnosed arthritis (C282Y/wild type (WT) adjusted OR = 1.041 (95% confidence interval (CI) 0.68–1.61), H63D/WT OR = 0.76 (95% CI 0.53–1.08), C282Y/C282Y OR = 0.39 (95% CI 0.04–3.63), C282Y/H 63D OR = 0.808 (95% CI 0.27–2.42), H63D/H63D OR = 0.419 (95% CI 0.13–1.36)). Overall adjusted OR for arthritis in participants with one or more HFE mutations was 0.81 (95% CI 0.61–1.09). Conclusions: Mutations of the HFE gene are not risk factors for arthritis in populations of British Isles descent.

Details

Title: Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis
Authors/Creators: C.A. Sherrington (Author/Creator) - Fremantle Hospital
M.W. Knuiman (Author/Creator) - School of Population Health,
M.L. Divitini (Author/Creator) - School of Population Health,
H.C. Bartholomew (Author/Creator) - School of Population Health,
D.J. Cullen (Author/Creator) - Fremantle Hospital
J.K. Olynyk (Author/Creator) - The University of Western Australia
Publication Details: Journal of Gastroenterology and Hepatology, Vol.21(3), pp.595-598
Publisher: Wiley-Blackwell
Identifiers: 991005540096307891
Copyright: © 2006 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.184 Physiology & Metals; 1.184.573 Iron Metabolism
Web Of Science research areas: Gastroenterology & Hepatology
ESI research areas: Clinical Medicine