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Journal article
Population dynamics of methicillin-susceptible and -resistant Staphylococcus aureus in remote communities
Journal of Antimicrobial Chemotherapy, Vol.64(4), pp.684-693
2009
Abstract
Objectives: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was first reported in remote regions of Western Australia (WA) in 1992 and is now the predominant MRSA isolated in the State. To gain insights into the emergence of CA-MRSA, 2146 people living in 11 remote WA communities were screened for colonization with S. aureus. Methods: Antibiogram analysis, contour-clamped homogeneous electric field electrophoresis, multilocus sequence typing, Panton-Valentine leucocidin determinant detection and accessory genetic regulator typing were performed to characterize the isolates. MRSA was further characterized by staphylococcal cassette chromosome mec typing. Results: The S. aureus population consisted of 13 clonal complexes and two Singleton lineages together with 56 sporadic isolates. Five lineages contained MRSA; however, these were not the predominant methicillin-susceptible S. aureus (MSSA) lineages. There was greater diversity amongst the MSSA while the MRSA appeared to have emerged clonally following acquisition of the staphylococcal cassette chromosome mec. Three MRSA lineages were considered to have been endemic in the communities and have subsequently become predominant lineages of CA-MRSA in the wider WA community. People colonized with MSSA tended to harbour clones of a different genetic lineage at each anatomical site while people colonized with MRSA tended to harbour clones of the same lineage at each site. Overall, the isolates were resistant to few antimicrobials. Conclusions: Although the evidence suggests that in WA CA-MRSA strains arose in remote communities and have now disseminated into the wider community, there is no evidence that they arose from the predominant MSSA clones in these communities.
Details
- Title
- Population dynamics of methicillin-susceptible and -resistant Staphylococcus aureus in remote communities
- Authors/Creators
- F.G. O'Brien (Author/Creator) - Curtin UniversityG.W. Coombs (Author/Creator) - Curtin UniversityJ.W. Pearman (Author/Creator) - Curtin UniversityM. Gracey (Author/Creator) - Government of Western Australia Department of HealthF. Moss (Author/Creator) - Government of Western Australia Department of HealthK.J. Christiansen (Author/Creator) - Curtin UniversityW.B. Grubb (Author/Creator) - Curtin University
- Publication Details
- Journal of Antimicrobial Chemotherapy, Vol.64(4), pp.684-693
- Publisher
- Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
- Identifiers
- 991005545416107891
- Copyright
- © The Author 2009.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology