Journal article
Post-Transplant HLA class II Antibodies and High Soluble CD30 Levels are Independently Associated with Poor Kidney Graft Survival
American Journal of Transplantation, Vol.7(4), pp.847-856
04/2007
Abstract
HLA-specific antibodies (HSA) and soluble CD30 (sCD30) were measured in 208 renal transplant recipients with functioning grafts at least 1 year after transplantation (median 8.2 years) to investigate the predictive value of HSA and sCD30 on subsequent graft outcome. HSA (class I and class II) were detected by both ELISA LAT-M and Luminex LabScreen assays. Data on graft outcome was collected with a median follow-up time of 3.5 years after antibody and sCD30 measurement. Recipients with post-transplant HLA class II antibodies had particularly poor graft outcome with a hazard ratio (HR) of 7.8 (p < 0.0001) when detected by ELISA, and a HR of 6.0 (p < 0.0001) when detected by Luminex. A high post-transplant sCD30 level ≥100 U/mL was associated with increased risk of subsequent graft failure (HR 2.7, p = 0.03). sCD30 and HSA had an independent and additive association with graft outcome. Recipients with HLA class II antibody and high sCD30 had the highest risk of subsequent graft failure (HR 43.4, p < 0.0001 and HR 18.1, p = 0.0008 for ELISA and Luminex, respectively). These data show that detection of HSA and serum sCD30 measured at least 1-year post-transplant provides valuable and predictive information regarding subsequent graft outcome.
Details
- Title
- Post-Transplant HLA class II Antibodies and High Soluble CD30 Levels are Independently Associated with Poor Kidney Graft Survival
- Authors/Creators
- L.L. Langan (Author/Creator)L.P. Park (Author/Creator)T.L. Hughes (Author/Creator)A. Irish (Author/Creator)G. Luxton (Author/Creator)C.S. Witt (Author/Creator)F.T. Christiansen (Author/Creator)
- Publication Details
- American Journal of Transplantation, Vol.7(4), pp.847-856
- Publisher
- Blackwell Publishing
- Identifiers
- 991005541863507891
- Copyright
- © 2007 The Authors.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.157 Organ Donation & Transplantation
- 1.157.1540 Antibody-Mediated Rejection
- Web Of Science research areas
- Surgery
- Transplantation
- ESI research areas
- Clinical Medicine