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CC BY V4.0, Open Access
Journal article
Postmortem Toxicology of Tadalafil in a Forensic Case
International journal of medical toxicology and forensic medicine, Vol.13(3), 40058
2023
Abstract
Tadalafil is an inhibitor of the human enzyme cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). As a mild vasodilator, it is primarily used for the treatment of erectile dysfunction, an increasingly common condition in men. It is also used for treatment of benign prostatic hyperplasia and pulmonary arterial hypertension. Adverse events of this drug are rare. Absolute contraindications include serious cardiac disease. Despite the widespread use of tadalafil, very little is known about its toxicology in forensic pathology and its association with post-mortem redistribution. This study presents a forensic case with possible contribution of tadalafil. The administration of tadalafil might act as a concurrent cause or contributing factor for lethal cardiogenic shock in people with cardiac disease.
Details
- Title
- Postmortem Toxicology of Tadalafil in a Forensic Case
- Authors/Creators
- Maria Laura Schirripa - University of ParmaLetizia Gnetti - University of ParmaEdda GuareschiSchool of Medicine, The University of Notre Dame Australia, Fremantle, Australia
- Publication Details
- International journal of medical toxicology and forensic medicine, Vol.13(3), 40058
- Publisher
- Shaheed Beheshti University of Medical Sciences and Health Services
- Identifiers
- 991005612269607891
- Copyright
- © Copyright 2023 Schirripa ML, et al.
- Murdoch Affiliation
- College of Environmental and Life Sciences; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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