Journal article
Potent bronchodilation and reduced stiffness by relaxant stimuli under dynamic conditions
European Respiratory Journal, Vol.33(4), pp.844-851
2009
Abstract
Airway relaxation in response to isoprenaline, sodium nitroprusside (SNP) and electrical field stimulation (EFS) was compared under static and dynamic conditions. The capacity of relaxants to reduce airway stiffness and, thus, potentially contribute to bronchodilation was also investigated. Relaxation responses were recorded in fluid filled bronchial segments from pigs under static conditions and during volume oscillations simulating tidal and twice tidal manoeuvres. Bronchodilation was assessed from the reduction in carbachol-induced lumen pressure, at isovolume points in pressure cycles produced by volume oscillation, and stiffness was assessed from cycle amplitudes. Under static conditions, all three inhibitory stimuli produced partial relaxation of the carbacholinduced contraction. Volume oscillation alone also reduced the contraction in an amplitude- dependent manner. However, maximum relaxation was observed when isoprenaline or SNP were combined with volume oscillation, virtually abolishing contraction at the highest drug concentrations. The proportional effects of isoprenaline and EFS were not different under static or oscillating conditions, whereas relaxation to SNP was slightly greater in oscillating airways. All three inhibitory stimuli also strongly reduced carbachol-induced airway stiffening. The current authors conclude that bronchoconstriction is strongly suppressed by combining the inhibitory stimulation of airway smooth muscle with cyclical mechanical strains. The capacity of airway smooth muscle relaxants to also reduce stiffness may further contribute to bronchodilation.
Details
- Title
- Potent bronchodilation and reduced stiffness by relaxant stimuli under dynamic conditions
- Authors/Creators
- T.K. Ansell (Author/Creator) - The University of Western AustraliaP.K. McFawn (Author/Creator) - School of Molecular SciencesP.B. Noble (Author/Creator) - School of Molecular SciencesA.R. West (Author/Creator) - School of Molecular SciencesL. Fernandes (Author/Creator) - School of Medicine and PharmacologyH.W. Mitchell (Author/Creator) - School of Molecular Sciences
- Publication Details
- European Respiratory Journal, Vol.33(4), pp.844-851
- Publisher
- European Respiratory Society
- Identifiers
- 991005545004407891
- Copyright
- © ERS Journals Ltd 2009.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.65 Allergy
- 1.65.44 Asthma
- Web Of Science research areas
- Respiratory System
- ESI research areas
- Clinical Medicine