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Potential link of single nucleotide polymorphisms to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa.pdf
Published (Version of Record)CC BY-NC-ND V4.0, Open Access
Journal article
Potential link of single nucleotide polymorphisms to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa
Transboundary and Emerging Diseases, Vol.67(6), pp.2946-2960
2020
Abstract
South Africa is endemic for lumpy skin disease and is therefore reliant on various live attenuated vaccines for the control and prevention of the disease. In recent years, widespread outbreaks of vaccine‐like strains of lumpy skin disease virus (LSDV) were reported internationally, leading to an increase in the generation of full genome sequences from field isolates. In this study, the complete genomes of six LSDVs submitted during active outbreaks in the 1990s in South Africa were generated. Based on phylogenetic analysis, the six viruses clustered with vaccine strains in LSDV Subgroup 1.1 and are subsequently referred to as vaccine‐associated. The genetic differences between the phenotypically distinct vaccine and vaccine‐associated strains were 67 single nucleotide polymorphisms (SNPs). This study characterized the location and possible importance of each of these SNPs in their role during virulence and host specificity.
Details
- Title
- Potential link of single nucleotide polymorphisms to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa
- Authors/Creators
- A. Schalkwyk (Author/Creator)P. Kara (Author/Creator)K. Ebersohn (Author/Creator)A. Mather (Author/Creator)C.H. Annandale (Author/Creator)E.H. Venter (Author/Creator)D.B. Wallace (Author/Creator)
- Publication Details
- Transboundary and Emerging Diseases, Vol.67(6), pp.2946-2960
- Publisher
- Wiley
- Identifiers
- 991005540745607891
- Copyright
- © 2020 Agricultural Research Council
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 1.161 Virology - Identification & Sequencing
- 1.161.1662 Poxvirus Immunology
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