Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease

P. Chatterjee; M. Fernando; B. Fernando; C.B. Dias; T. Shah; R. Silva; S. Williams; S. Pedrini; H. Hillebrandt; K. Goozee; E. Barin; H.R. Sohrabi; M. Garg; S. Cunnane; R.N. Martins

doi:10.1016/j.mad.2020.111209

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Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease

Journal article

Peer reviewed

Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease

P. Chatterjee, M. Fernando, B. Fernando, C.B. Dias, T. Shah, R. Silva, S. Williams, S. Pedrini, H. Hillebrandt, K. Goozee, …

Mechanisms of Ageing and Development, Vol.186, Article 111209

2020

DOI: https://doi.org/10.1016/j.mad.2020.111209

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia. Currently, there is no effective medication for the prevention or treatment of AD. This has led to the search for alternative therapeutic strategies. Coconut oil(CO) has a unique fatty acid composition that is rich in medium chain fatty acids(MCFA), a major portion of which directly reaches the liver via the portal vein, thereby bypassing the lymphatic system. Given that brain glucose hypometabolism is a major early hallmark of AD, detectable well before the onset of symptoms, ketone bodies from MCFA metabolism can potentially serve as an alternative energy source to compensate for lack of glucose utilisation in the brain. Additionally, neuroprotective antioxidant properties of CO have been attributed to its polyphenolic content. This review discusses how the metabolism of CO and MCFA may aid in compensating the glucose hypometabolism observed in the AD brain. Furthermore, we present the current evidence of the neuroprotective properties of CO on cognition, amyloid-β pathogenicity, inflammation and oxidative stress. The current review addresses the influence of CO/MCFA on other chronic disorders that are risk factors for AD, and addresses existing gaps in the literature regarding the use of CO/MCFA as a potential treatment for AD.

Details

Title: Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease
Authors/Creators: P. Chatterjee (Author/Creator) - Edith Cowan University
M. Fernando (Author/Creator) - Wayamba University of Sri Lanka
B. Fernando (Author/Creator) - Edith Cowan University
C.B. Dias (Author/Creator) - Macquarie University
T. Shah (Author/Creator) - Edith Cowan University
R. Silva (Author/Creator) - Wayamba University of Sri Lanka
S. Williams (Author/Creator) - University of Kelaniya
S. Pedrini (Author/Creator) - Edith Cowan University
H. Hillebrandt (Author/Creator) - Macquarie University
K. Goozee (Author/Creator) - Cooperative Research Centre
E. Barin (Author/Creator) - Macquarie University
H.R. Sohrabi (Author/Creator) - Edith Cowan University
M. Garg (Author/Creator) - University of Newcastle Australia
S. Cunnane (Author/Creator) - Université de Sherbrooke
R.N. Martins (Author/Creator) - Macquarie University
Publication Details: Mechanisms of Ageing and Development, Vol.186, Article 111209
Publisher: Elsevier
Identifiers: 991005542817907891
Copyright: © 2020 Published by Elsevier B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.5 Neuroscience; 1.5.1674 Astrocytes & Ketogenic Diet
Web Of Science research areas: Cell Biology; Geriatrics & Gerontology
ESI research areas: Molecular Biology & Genetics