Journal article
Potential roles for uncoupling proteins in HIV lipodystrophy
Mitochondrion, Vol.4(2-3), pp.185-191
2004
Abstract
The ‘HIV lipodystrophy syndrome’ consists of several distinct components, including lipoatrophy (pathological subcutaneous fat loss), lipohypertrophy (abdominal/visceral adiposity), and metabolic complications including insulin resistance and dyslipidemia. Lipoatrophy appears to represent an adipose tissue-specific form of mitochondrial toxicity associated strongly with stavudine NRTI therapy, whilst the ‘metabolic syndrome’ phenotype is associated with HIV protease inhibitor therapy. In this context, the role of uncoupling proteins (UCPs) in modulating resting energy expenditure in response to elevated fatty acid flux associated with the ‘metabolic syndrome’ is supported by clinical data as well as findings of elevated adipose tissue UCP expression. The role of UCPs in this syndrome therefore exemplifies the multifactorial nature of these antiretroviral therapy complications.
Details
- Title
- Potential roles for uncoupling proteins in HIV lipodystrophy
- Authors/Creators
- D. Nolan (Author/Creator) - Royal Perth HospitalC. Pace (Author/Creator) - Royal Perth Hospital
- Publication Details
- Mitochondrion, Vol.4(2-3), pp.185-191
- Publisher
- Elsevier B.V.
- Identifiers
- 991005540176607891
- Copyright
- 2004 Elsevier B.V.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1372 HIV Comorbidities
- Web Of Science research areas
- Cell Biology
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics