Journal article
Potentiometric and computer studies of yttrium-EDTMP
Inorganica Chimica Acta, (275-276), pp.39-42
1998
Abstract
The metal complex, Y-EDTMP (EDTMP=ethylenediaminetetra(methylenephosphonic) acid) has been evaluated as a bone therapeutic radiopharmaceutical. Its solution chemistry has been characterised in order to model its speciation in blood plasma and to compare it with that of Sm-EDTMP. The formation constants of the complexes of Y-EDTMP were measured by glass electrode potentiometry at 25°C in 0.15 M NaCl. The following values were obtained: log β11-1 ([Y(EDTMP)H-1]6-) = 3.935, log β110 ([YEDTMP]5-) = 11.106, log β111 ([Y(EDTMP)H]4-) = 17.001 and log β112 ([Y(EDTMP)H2]3-) = 22.808. Computer simulations indicate that [YEDTMP]5- and the hydroxy species [Y(EDTMP)H-1]6- are the major yttrium(III) complexes and that calcium ions are probably the major competitor for EDTMP in blood plasma.
Details
- Title
- Potentiometric and computer studies of yttrium-EDTMP
- Authors/Creators
- G.C. De Witt (Author/Creator)P.M. May (Author/Creator)J. Webb (Author/Creator)G. Hefter (Author/Creator)
- Publication Details
- Inorganica Chimica Acta, (275-276), pp.39-42
- Publisher
- Elsevier BV
- Identifiers
- 991005541718807891
- Copyright
- © 1998 Elsevier Science S.A. All rights reserved.
- Murdoch Affiliation
- School of Chemical and Mathematical Science
- Language
- English
- Resource Type
- Journal article
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