Journal article
Power calculations for selective genotyping in QTL mapping in backcross mice
Genetical Research, Vol.84(2), pp.103-108
2004
Abstract
Selective genotyping concerns the genotyping of a portion of individuals chosen on the basis of their phenotypic values. Often individuals are selected for genotyping from the high and low extremes of the phenotypic distribution. This procedure yields savings in cost and time by decreasing the total number of individuals genotyped. Previous work by Darvasi et al. (1993) has shown that the power to detect a QTL by genotyping 40–50% of a population is roughly equivalent to genotyping the entire sample. However, these power studies have not accounted for different strategies of analysing the data when phenotypes of individuals in the middle are excluded, nor have they investigated the genome-wide type I error rate under these different strategies or different selection percentages. Further, these simulation studies have not considered markers over the entire genome. In this paper, we present simulation studies of power for the maximum likelihood approach to QTL mapping by Lander & Botstein (1989) in the context of selective genotyping. We calculate the power of selectively genotyping the individuals from the middle of the phenotypic distribution when performing QTL mapping over the whole mouse genome.
Details
- Title
- Power calculations for selective genotyping in QTL mapping in backcross mice
- Authors/Creators
- N. Rabbee (Author/Creator) - University of California, BerkeleyD. Speca (Author/Creator) - Ernest Gallo Clinic and Research CenterN.J. Armstrong (Author/Creator) - Atomic Energy (Canada)T.P. Speed (Author/Creator) - Walter and Eliza Hall Institute of Medical Research
- Publication Details
- Genetical Research, Vol.84(2), pp.103-108
- Publisher
- Cambridge University Press
- Identifiers
- 991005542671407891
- Copyright
- © 2004 Cambridge University Press
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.4 Crop Science
- 3.4.96 QTL
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics