Journal article
Praziquantel adversely affects protoscoleces of Echinococcus granulosus in vitro
Journal of Helminthology, Vol.60(04), pp.279-286
1986
Abstract
Praziquantel was shown to have adverse effects on protoscoleces of Echinococcus granulosus in vitro. Exposure to one dose of praziquantel at a concentration of 10μg/ml caused protoscoleces to die within 12 to 15 days. Protoscolecidal effects were more marked when cultures were exposed to the drug continuously by the addition of multiple doses. On the basis of these observations, there is a need to reappraise the metacestocidal potential of praziquantel, particularly with regard to the development of new drug regimes employing multiple dose or sustained release schedules. Possible reasons for the reduced susceptibility of protoscoleces and juvenile worms to praziquantel observed in this study are discussed.
Details
- Title
- Praziquantel adversely affects protoscoleces of Echinococcus granulosus in vitro
- Authors/Creators
- R.C.A. Thompson (Author/Creator)J.A. Reynoldson (Author/Creator)C.R. Riddler (Author/Creator)
- Publication Details
- Journal of Helminthology, Vol.60(04), pp.279-286
- Publisher
- Cambridge University Press
- Identifiers
- 991005541290707891
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.1106 Echinococcosis
- Web Of Science research areas
- Parasitology
- Zoology
- ESI research areas
- Plant & Animal Science