Journal article
Predicting diagnosis of Australian canine and feline urinary bladder disease based on histologic features
Veterinary Sciences, Vol.7(4), Article 190
2020
Abstract
Anatomic pathology is a vital component of veterinary medicine but as a primarily subjective qualitative or semiquantitative discipline, it is at risk of cognitive biases. Logistic regression is a statistical technique used to explain relationships between data categories and outcomes and is increasingly being applied in medicine for predicting disease probability based on medical and patient variables. Our aims were to evaluate histologic features of canine and feline bladder diseases and explore the utility of logistic regression modeling in identifying associations in veterinary histopathology, then formulate a predictive disease model using urinary bladder as a pilot tissue. The histologic features of 267 canine and 71 feline bladder samples were evaluated, and a logistic regression model was developed to identify associations between the bladder disease diagnosed, and both patient and histologic variables. There were 102 cases of cystitis, 84 neoplasia, 42 urolithiasis and 63 normal bladders. Logistic regression modeling identified six variables that were significantly associated with disease outcome: species, urothelial ulceration, urothelial inflammation, submucosal lymphoid aggregates, neutrophilic submucosal inflammation, and moderate submucosal hemorrhage. This study demonstrated that logistic regression modeling could provide a more objective approach to veterinary histopathology and has opened the door toward predictive disease modeling based on histologic variables.
Details
- Title
- Predicting diagnosis of Australian canine and feline urinary bladder disease based on histologic features
- Authors/Creators
- E. Jones (Author/Creator)J. Alawneh (Author/Creator)M. Thompson (Author/Creator)C. Palmieri (Author/Creator)K. Jackson (Author/Creator)R. Allavena (Author/Creator)
- Publication Details
- Veterinary Sciences, Vol.7(4), Article 190
- Publisher
- MDPI
- Identifiers
- 991005541873907891
- Copyright
- © 2020 by the authors
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.243 Kidney Diseases
- 1.243.519 Urolithiasis
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science