Journal article
Predicting the risk of cardiovascular disease in HIV-infected patients: The Data collection on Adverse Effects of Anti-HIV Drugs Study
European Journal of Cardiovascular Prevention & Rehabilitation, Vol.17(5), pp.491-501
2010
Abstract
Aims: HIV-infected patients receiving combination antiretroviral therapy may experience metabolic complications, potentially increasing their risk of cardiovascular diseases (CVDs). Furthermore, exposures to some antiretroviral drugs seem to be independently associated with increased CVD risk. We aimed to develop cardiovascular risk-assessment models tailored to HIV-infected patients.
Methods and results: Prospective multinational cohort study. The data set included 22 625 HIV-infected patients from 20 countries in Europe and Australia who were free of CVD at entry into the Data collection on Adverse Effects of Anti-HIV Drugs Study. Using cross-validation methods, separate models were developed to predict the risk of myocardial infarction, coronary heart disease, and a composite CVD endpoint. Model performance was compared with the Framingham score. The models included age, sex, systolic blood pressure, smoking status, family history of CVD, diabetes, total cholesterol, HDL cholesterol and indinavir, lopinavir/r and abacavir exposure. The models performed well with area under the receiver operator curve statistics of 0.783 (range 0.642–0.820) for myocardial infarction, 0.776 (0.670–0.818) for coronary heart disease and 0.769 (0.695–0.824) for CVD. The models estimated more accurately the outcomes in the subgroups than the Framingham score.
Conclusion: Risk equations developed from a population of HIV-infected patients, incorporating routinely collected cardiovascular risk parameters and exposure to individual antiretroviral therapy drugs, might be more useful in estimating CVD risks in HIV-infected persons than conventional risk prediction models.
Details
- Title
- Predicting the risk of cardiovascular disease in HIV-infected patients: The Data collection on Adverse Effects of Anti-HIV Drugs Study
- Authors/Creators
- N. Friis-Møller (Author/Creator) - Copenhagen HIV Programme (CHIP), University of Copenhagen/Faculty of Health Science, Copenhagen, DenmarkR. Thiébaut (Author/Creator) - Université Bordeaux SegalenP. Reiss (Author/Creator) - Amsterdam UMC Location University of AmsterdamR. Weber (Author/Creator) - University Hospital of ZurichA.D. Monforte (Author/Creator) - University of MilanS. De Wit (Author/Creator) - Centre Hospitalier Universitaire de Saint-PierreW. El-Sadr (Author/Creator) - Harlem Hospital CenterE. Fontas (Author/Creator) - L'ArcheS. Worm (Author/Creator) - Copenhagen HIV Programme (CHIP), University of Copenhagen/Faculty of Health Science, Copenhagen, DenmarkO. Kirk (Author/Creator) - Copenhagen HIV Programme (CHIP), University of Copenhagen/Faculty of Health Science, Copenhagen, DenmarkA. Phillips (Author/Creator) - University College LondonC.A. Sabin (Author/Creator) - AHOD, National Centre in HIV Epidemiology and Clinical Research, Sydney, AustraliaJ.D. Lundgren (Author/Creator) - Copenhagen HIV Programme (CHIP), University of Copenhagen/Faculty of Health Science, Copenhagen, DenmarkM.G. Law (Author/Creator) - University College LondonS. Mallal (Author/Creator)D. Nolan (Author/Creator)
- Publication Details
- European Journal of Cardiovascular Prevention & Rehabilitation, Vol.17(5), pp.491-501
- Publisher
- SAGE
- Identifiers
- 991005540084307891
- Copyright
- 2010 The European Society of Cardiology
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
- Note
- Simon Mallal & David Nolan appear on behalf of the D:A:D Study Group
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1372 HIV Comorbidities
- Web Of Science research areas
- Cardiac & Cardiovascular Systems
- ESI research areas
- Clinical Medicine