Abstract
Concomitant administration of Japanese encephalitis (JE) and other travel-related vaccines is common, yet safety data on these combinations remain limited. This study applies machine learning (ML) techniques to predict adverse events following immunisation (AEFI) using active surveillance data from Australian travellers. Five ML models were evaluated, with random forest demonstrating the highest predictive performance. Important predictors included age, number of vaccines received, and specific vaccine types. The final model was implemented in an interactive web-based tool to support clinical decision-making and improve communication of AEFI risk. This approach demonstrates the potential of ML to enhance vaccine safety monitoring in travel medicine.