Journal article
Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts
AIDS, Vol.19(1), pp.97-99
2005
Abstract
Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort. Cases involving combinations of hepatitis, fever or rash were associated with an interaction between HLA-DRB1*0101 and the percentage of CD4, whereas no associations were detected for isolated rash. These data suggest that HLA-DRB1*0101 and the CD4 status may determine susceptibility to nevirapine hypersensitivity, consistent with a CD4 T-cell-dependent immune response to nevirapine-specific antigens.
Details
- Title
- Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts
- Authors/Creators
- A.M. Martin (Author/Creator)D. Nolan (Author/Creator)I. James (Author/Creator)P. Cameron (Author/Creator)J. Keller (Author/Creator)C. Moore (Author/Creator)E. Phillips (Author/Creator)F.T. Christiansen (Author/Creator)S. Mallal (Author/Creator)
- Publication Details
- AIDS, Vol.19(1), pp.97-99
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005541786007891
- Copyright
- © 2005 Lippincott Williams & Wilkins, Inc.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
Metrics
25 Record Views