Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort

J-S Wu; W. Qiu; A. Castley; I. James; J. Joseph; F.T. Christiansen; W.M. Carroll; F.L. Mastaglia; A.G. Kermode

doi:10.1016/j.jns.2009.10.005

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Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort

Journal article

Peer reviewed

Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort

J-S Wu, W. Qiu, A. Castley, I. James, J. Joseph, F.T. Christiansen, W.M. Carroll, F.L. Mastaglia and A.G. Kermode

Journal of the Neurological Sciences, Vol.288(1-2), pp.63-67

2010

DOI: https://doi.org/10.1016/j.jns.2009.10.005

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Abstract

High-resolution HLA-DRB1 genotyping was performed in 97 OCB-positive and 68 OCB-negative cases with demyelinating disease to determine the influence of HLA-DRB1 alleles on the presence of OCB in a West Australian multiple sclerosis (MS) cohort. Carriage of the HLA-DRB1*1501 allele was associated with both OCB-positive and OCB-negative MS compared with controls, but more strongly with the OCB-positive group, and increased the likelihood of having OCB 2.1-fold with evidence of a dominant dose-effect. The HLA-DRB1*0301 allele was negatively correlated with OCB, with all homozygotes OCB-negative, suggesting a possible recessive protective effect of HLA-DRB1*0301. There was no significant correlation between OCB and the DRB1*04 alleles which have been associated with OCB-negative MS in previous Swedish and Japanese studies. Evidence of allelic interactions was found with HLA-DRB1*1501/*1301 heterozygotes having a reduced frequency of OCB and HLA-DRB1*0301/*0401 heterozygotes all being OCB-negative. These findings confirm the strong association between HLA-DRB1*1501 and OCB which has been found in other populations but indicate that the influence of other HLA-DRB1 alleles varies in different populations. Our study is the first to show that HLA-DRB1 allele interactions and dose-effects influence the frequency of OCB.

Details

Title: Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort
Authors/Creators: J-S Wu (Author/Creator) - Sir Charles Gairdner Hospital
W. Qiu (Author/Creator) - Sir Charles Gairdner Hospital
A. Castley (Author/Creator) - Royal Perth Hospital
I. James (Author/Creator) - Royal Perth Hospital
J. Joseph (Author/Creator) - Sir Charles Gairdner Hospital
F.T. Christiansen (Author/Creator) - Royal Perth Hospital
W.M. Carroll (Author/Creator) - Sir Charles Gairdner Hospital
F.L. Mastaglia (Author/Creator) - Sir Charles Gairdner Hospital
A.G. Kermode (Author/Creator) - Sir Charles Gairdner Hospital
Publication Details: Journal of the Neurological Sciences, Vol.288(1-2), pp.63-67
Publisher: Elsevier BV
Identifiers: 991005541766207891
Copyright: © 2009 Elsevier B.V.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior