Journal article
Presumptive Nocardia spp. infection in a dog treated with cyclosporin and ketoconazole
New Zealand Veterinary Journal, Vol.58(5), pp.265-268
2010
Abstract
CASE HISTORY: A dog that had received 8 months of cyclosporin and ketoconazole therapy for treatment of atopic dermatitis subsequently developed severe neurological disease, that failed to respond to treatment with trimethoprim-sulphadiazine and clindamycin.
HISTOPATHOLOGICAL FINDINGS: Histopathological examination of the pulmonary parenchyma and spinal cord revealed loose aggregates of Gram-positive, partially acid-fast, fine, beaded, filamentous bacteria, most consistent with Nocardia spp.
DIAGNOSIS: A presumptive diagnosis was made of disseminated nocardiosis of the spinal cord and lungs.
CLINICAL RELEVANCE: Nocardia spp. is an opportunistic actinomycete that may cause disseminated disease, particularly in immunocompromised animals. Cyclosporin is used in veterinary medicine to control immune-mediated and allergic disorders, with few reported adverse side effects. This case gives further evidence that involvement of the spinal cord in nocardiosis of the central nervous system (CNS) carries a poor prognosis, and opportunistic infection by Nocardia spp. may be a potential complication of immunosuppressive cyclosporin therapy in the dog.
Details
- Title
- Presumptive Nocardia spp. infection in a dog treated with cyclosporin and ketoconazole
- Authors/Creators
- A.E.H. Paul (Author/Creator)C.S. Mansfield (Author/Creator)M. Thompson (Author/Creator)
- Publication Details
- New Zealand Veterinary Journal, Vol.58(5), pp.265-268
- Publisher
- New Zealand Veterinary Association
- Identifiers
- 991005544985207891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.324 Bacterial Toxins & Diseases
- 1.324.1987 Actinomycosis and Nocardiosis
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science