Prevalence of anthelmintic resistant cyathostomes on horse farms

R.M. Kaplan; T.R. Klei; E.T. Lyons; G. Lester; C.H. Courtney; D.D. French; S.C. Tolliver; A.N. Vidyashankar; Y. Zhao

doi:10.2460/javma.2004.225.903

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Prevalence of anthelmintic resistant cyathostomes on horse farms

Journal article

Peer reviewed

Prevalence of anthelmintic resistant cyathostomes on horse farms

R.M. Kaplan, T.R. Klei, E.T. Lyons, G. Lester, C.H. Courtney, D.D. French, S.C. Tolliver, A.N. Vidyashankar and Y. Zhao

Journal of the American Veterinary Medical Association, Vol.225(6), pp.903-910

2004

DOI: https://doi.org/10.2460/javma.2004.225.903

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Abstract

Objective-To determine prevalence of anthelmintic resistance in cyathostome nematodes of horses in the southern United States. Design-Cross-sectional study. Animals-786 horses on 44 farms and stables in Georgia, South Carolina, Florida, Kentucky, and Louisiana. Procedure-Fecal egg count (FEC) reduction tests were performed on 44 large farms and stables. Horses on each farm were treated with an oral paste formulation of fenbendazole, oxibendazole, pyrantel pamoate, or ivermectin at recommended label dosages. A mixed linear model was fitted to the percentage reduction in FEC, accounting for differences among farms, states, ages, treatments, and treatment by state interactions. Results-By use of a conservative measure of resistance (< 80% reduction), the percentage of farms with anthelmintic-resistant cyathostomes was 977%, 0%, 53.5%, and 40.5% for fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate, respectively. Mean percentage reductions in FEC for all farms were 24.8%, 99.9%, 73.8%, and 78.6% for fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate, respectively. Pairwise contrasts between states for each treatment revealed that in almost all instances, there were no significant differences in results between states. Conclusions and Clinical Relevance-The prevalence of resistance found in this study was higher than that reported previously, suggesting that anthelmintic resistance in equine cyathostomes is becoming a major problem. Furthermore, data from these 5 southern states, which are geographically and physiographically distinct, were remarkably similar. This suggests that drug resistance in cyathostomes is highly prevalent throughout the entire southern United States and probably nationwide.

Details

Title: Prevalence of anthelmintic resistant cyathostomes on horse farms
Authors/Creators: R.M. Kaplan (Author/Creator) - University of Georgia
T.R. Klei (Author/Creator) - Louisiana State University
E.T. Lyons (Author/Creator) - University of Kentucky
G. Lester (Author/Creator) - Murdoch University
C.H. Courtney (Author/Creator) - University of Florida Health
D.D. French (Author/Creator) - Louisiana State University
S.C. Tolliver (Author/Creator) - University of Kentucky
A.N. Vidyashankar (Author/Creator) - University of Georgia
Y. Zhao (Author/Creator) - University of Georgia
Publication Details: Journal of the American Veterinary Medical Association, Vol.225(6), pp.903-910
Publisher: American Veterinary Medical Association
Identifiers: 991005540179607891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.1022 Anthelmintic Resistance
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science