Prevalence of antinuclear antibodies and rheumatoid factor titers in dogs with arthritis secondary to leishmaniosis (Leishmania infantum)

T.K. Tsouloufi; K. Theodorou; M.J. Day; I.L. Oikonomidis; D. Kasabalis; M.E. Mylonakis; M.N. Saridomichelakis; M. Kritsepi-Konstantinou; N. Soubasis

doi:10.1177/10406387221099030

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Prevalence of antinuclear antibodies and rheumatoid factor titers in dogs with arthritis secondary to leishmaniosis (Leishmania infantum)

Journal article

Peer reviewed

Prevalence of antinuclear antibodies and rheumatoid factor titers in dogs with arthritis secondary to leishmaniosis (Leishmania infantum)

T.K. Tsouloufi, K. Theodorou, M.J. Day, I.L. Oikonomidis, D. Kasabalis, M.E. Mylonakis, M.N. Saridomichelakis, M. Kritsepi-Konstantinou and N. Soubasis

Journal of Veterinary Diagnostic Investigation

2022

DOI: https://doi.org/10.1177/10406387221099030

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Abstract

Dogs with infectious arthritis may occasionally exhibit positive serum antinuclear antibody (ANA) and rheumatoid factor (RF) titers; however, relevant data are sparse for arthritis secondary to canine leishmaniosis (CanL) caused by Leishmania infantum. We determined the prevalence of positive serum ANA and RF titers in dogs with arthritis secondary to CanL. Blood samples from adult, client-owned dogs with purulent arthritis secondary to CanL, without any comorbidities, were collected for diagnostic purposes. Serum ANA titers were measured by immunoperoxidase test and RF titers by the Rose–Waaler latex test. Twelve of 23 dogs enrolled prospectively in our study had clinical arthritis, and 11 of 23 had subclinical arthritis. Based on LeishVet clinical staging, 7 dogs had clinical stage II disease, 11 had clinical stage III disease, and 5 had stage IV. None of the 23 dogs was seropositive for ANA; 3 of 23 were positive for RF. ANA and/or RF seropositivity, in dogs with CanL-associated arthritis, appears to be weak, if present at all. Based on our results, positive serum ANA and RF titers should not be expected in dogs with arthritis secondary to CanL.

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Title: Prevalence of antinuclear antibodies and rheumatoid factor titers in dogs with arthritis secondary to leishmaniosis (Leishmania infantum)
Authors/Creators: T.K. Tsouloufi (Author/Creator) - Aristotle University of Thessaloniki
K. Theodorou (Author/Creator) - Aristotle University of Thessaloniki
M.J. Day (Author/Creator) - Murdoch University
I.L. Oikonomidis (Author/Creator) - Aristotle University of Thessaloniki
D. Kasabalis (Author/Creator) - University of Thessaly
M.E. Mylonakis (Author/Creator) - Aristotle University of Thessaloniki
M.N. Saridomichelakis (Author/Creator) - University of Thessaly
M. Kritsepi-Konstantinou (Author/Creator) - Aristotle University of Thessaloniki
N. Soubasis (Author/Creator) - Aristotle University of Thessaloniki
Publication Details: Journal of Veterinary Diagnostic Investigation
Publisher: American Association of Veterinary Laboratory Diagnosticians
Identifiers: 991005540766407891
Copyright: © 2022 by American Association of Veterinary Laboratory Diagnosticians
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.261 Parasitology - Trypanosoma & Leishmania; 1.261.695 Leishmaniasis Dynamics
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science