Journal article
Primary orbital melanoma arising in an atypical diffuse (plaque-like) blue naevus/melanocytosis: a case report and review of literature
BMC Ophthalmology, Vol.21(1), Art. 425
2021
Abstract
Background
Primary orbital melanoma is a rare disease and can occasionally develop from a pre-existing neoplasm of the blue naevus family of melanocytic lesions.
Case presentation
Herein we report a rare case of primary orbital melanoma arising from an unusual atypical diffuse (plaque-like) blue naevus/melanocytosis. A 27 year old man presented with mild pain and swelling of the left eye. Magnetic Resonance Imaging revealed a left lateral episcleral orbital mass and an incisional biopsy confirmed the diagnosis of malignant melanoma. Skin-sparing total left orbital exenteration was performed. Histopathological examination of the exenteration specimen revealed a primary orbital melanoma arising in a pre-existing blue naevus like melanocytosis.
We demonstrate the evidence for histological progression, characterise the molecular profile of this tumour and discuss the related literature.
Conclusions
This case emphasises the importance of a meticulous clinicopathological correlation in recognising such a tumour as a primary orbital melanoma rather than a metastasis, which is managed differently.
Details
- Title
- Primary orbital melanoma arising in an atypical diffuse (plaque-like) blue naevus/melanocytosis: a case report and review of literature
- Authors/Creators
- T-A Dickens (Author/Creator) - The University of Western AustraliaM. Franchina (Author/Creator) - Lions Eye InstituteA. Gajdatsy (Author/Creator) - The University of Western AustraliaN. Mesbah Ardakani (Author/Creator)
- Publication Details
- BMC Ophthalmology, Vol.21(1), Art. 425
- Publisher
- BioMed Central Ltd as part of Springer Nature
- Identifiers
- 991005545519707891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.158 Dermatology - General
- 1.158.201 Melanoma Research
- Web Of Science research areas
- Ophthalmology
- ESI research areas
- Clinical Medicine