Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus

T. McNab; M. Desport; R. Dobson; I.W. Tenaya; N. Hartaningsih; G.E. Wilcox

doi:10.1016/j.virol.2010.05.001

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Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus

Journal article

Peer reviewed

Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus

T. McNab, M. Desport, R. Dobson, I.W. Tenaya, N. Hartaningsih and G.E. Wilcox

Virology, Vol.404(2), pp.261-268

2010

DOI: https://doi.org/10.1016/j.virol.2010.05.001

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Abstract

Bovine immunodeficiency virus

Jembrana disease virus

Bali cattle

Immune response

Lentivirus

Superinfection

In cattle the interaction between the two genetically and antigenically related bovine lentiviruses, the acutely pathogenic Jembrana disease virus (JDV) and the non-pathogenic Bovine immunodeficiency virus (BIV) has not been reported although both JDV and a BIV-like virus have been reported in the Bali cattle (Bos javanicus) population in Indonesia. The outcome of infection of Bali cattle with the R29 strain of BIV prior to superinfection 42 days later with JDVTAB/87 was determined. All BIV-inoculated cattle were successfully infected and developed an antibody response to the TM and CA proteins. BIV infection did not prevent subsequent infection with JDV or ameliorate the clinical signs of Jembrana disease in the infected cattle. It did, however, modify the dynamics of the JDV infection with an earlier onset and end of the acute disease process, and a reduction in the duration of viremia that exceeded 106 genome copies/ml of plasma.

Details

Title: Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus
Authors/Creators: T. McNab (Author/Creator)
M. Desport (Author/Creator)
R. Dobson (Author/Creator)
I.W. Tenaya (Author/Creator)
N. Hartaningsih (Author/Creator)
G.E. Wilcox (Author/Creator)
Publication Details: Virology, Vol.404(2), pp.261-268
Publisher: Academic Press
Number of pages: 8
Identifiers: 991005541267907891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Virology
ESI research areas: Microbiology