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Author’s VersionCC BY-NC-ND V4.0, Open Access
Journal article
Procalcitonin concentrations as a predictor of unexpected readmission and mortality after intensive care unit discharge: A retrospective cohort study
Journal of Critical Care, Vol.33, pp.240-244
2016
Abstract
Procalcitonin (PCT) has been used to guide treatment in critically ill patients with sepsis, but whether PCT at intensive care unit (ICU) discharge can stratify risks of post-ICU readmission or mortality is unknown. This cohort study compared the ability of PCT to C-reactive protein (CRP) in predicting unexpected adverse post-ICU events. Of the 1877 patients admitted to the multidisciplinary ICU between 1 April 2012 and 31 March 2014, 1653 (88.1%) were discharged without treatment limitations. A total of 71 (4.3%) were readmitted and 18 patients (1%) died unexpectedly after ICU discharge during the same hospitalization. Both PCT (0.6 vs. 0.4ug/L, p=0.002) and a high CRP concentration > 100mg/L (58% vs. 41%, p=0.004) at ICU discharge were associated with an increased risk of adverse post-ICU events in the univariate analyses, however the ability of PCT to discriminate between patients with and without adverse post-ICU outcomes was limited (area under the receiver-operating-characteristic curve = 0.61, 95% confidence interval [CI]: 0.55-0.66). In the multivariable analysis, only a high CRP concentration (odds ratio 1.92, 95%CI: 1.12-3.11; p=0.008) was associated with an increased adverse post-ICU events. Elevated PCT concentration at ICU discharge was inadequate in its predictive ability to guide ICU discharge.
Details
- Title
- Procalcitonin concentrations as a predictor of unexpected readmission and mortality after intensive care unit discharge: A retrospective cohort study
- Authors/Creators
- G. Zhou (Author/Creator) - Royal Perth HospitalK.M. Ho (Author/Creator) - The University of Western Australia
- Publication Details
- Journal of Critical Care, Vol.33, pp.240-244
- Publisher
- Elsevier B.V.
- Identifiers
- 991005541914107891
- Copyright
- © 2016 Elsevier B.V.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.360 Procalcitonin
- Web Of Science research areas
- Critical Care Medicine
- ESI research areas
- Clinical Medicine