Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults

J. Lu; Y. Huang; Y. Wang; Y. Li; Y. Zhang; J. Wu; F. Zhao; S. Meng; X. Yu; Q. Ma; M. Song; N. Chang; A.H. Bittles; W. Wang

doi:10.1371/journal.pone.0039726

Back

Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults

Journal article

Open access

Peer reviewed

Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults

J. Lu, Y. Huang, Y. Wang, Y. Li, Y. Zhang, J. Wu, F. Zhao, S. Meng, X. Yu, Q. Ma, …

PLoS ONE, Vol.7(7), e39726

2012

DOI: https://doi.org/10.1371/journal.pone.0039726

Files and links (2)

pdf

profiling_plasma_peptides.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.

Details

Title: Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults
Authors/Creators: J. Lu (Author/Creator) - Capital Medical University
Y. Huang (Author/Creator) - Beijing Haidian Hospital
Y. Wang (Author/Creator) - Capital Medical University
Y. Li (Author/Creator) - OG Technologies (United States)
Y. Zhang (Author/Creator) - OG Technologies (United States)
J. Wu (Author/Creator) - Capital Medical University
F. Zhao (Author/Creator) - Capital Medical University
S. Meng (Author/Creator) - Capital Medical University
X. Yu (Author/Creator) - Capital Medical University
Q. Ma (Author/Creator) - OG Technologies (United States)
M. Song (Author/Creator) - Capital Medical University
N. Chang (Author/Creator) - Beijing Hospital
A.H. Bittles (Author/Creator) - Murdoch University
W. Wang (Author/Creator) - Capital Medical University
Publication Details: PLoS ONE, Vol.7(7), e39726
Publisher: Public Library of Science
Identifiers: 991005542255907891
Copyright: © 2012 Lu et al
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article
Note: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

205 File views/ downloads

45 Record Views

30 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.211 Mass Spectrometry; 2.211.497 Proteomics Mass Spectrometry
Web Of Science research areas: Geriatrics & Gerontology
ESI research areas: Clinical Medicine