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CC BY-NC-ND V4.0, Open Access
Journal article
Progressive hepatopathy after central division hepatectomy in a dog
Australian veterinary journal, Vol.103(7), pp.422-429
2025
PMID: 40457811
Appears in Open Access via Read & Publish Agreements
Abstract
The consequences of large-volume hepatectomy on the remaining liver in the dog are not documented. This case report documents a progressive hepatopathy after central division hepatectomy in a 10-year-old female Lhasa Apso dog. Serum biochemistry at presentation for chronic urinary incontinence indicated a hepatopathy, with a liver mass identified on subsequent ultrasound. Referral for computed tomography (CT) (day 76) demonstrated a central division liver mass (~204cm
). A central division hepatectomy (right medial and quadrate lobes; gallbladder) was performed, with microscopic examination confirming a hepatocellular carcinoma. Serial biochemistry over a three-and-a-half-year follow-up documented progressive hepatopathy. Serial CT hepatic volumetry (day 76, 136, 1041) documented gross enlargement of the residual right lateral liver lobe and gross reduction of the residual left medial and lateral liver lobes. Biopsies of the left and right liver (day 187) demonstrated disparate pathology with microscopic features consistent with regeneration in the right liver and elevated portal vein pressure (PVP) in the left liver. This report documents progressive hepatopathy evidenced by serum biochemistry, disparate and persistent gross liver changes on posthepatectomy CT, and microscopic changes consistent with elevated PVP. Findings from this case demonstrate similarities to posthepatectomy liver failure (PHLF) and small-for-size-and-flow syndrome (SFSS) as reported in people and animal models. The progressive hepatopathy posthepatectomy in this case prompts consideration and further investigation for the development of PHLF and SFSS in the dog.
Details
- Title
- Progressive hepatopathy after central division hepatectomy in a dog
- Authors/Creators
- S J Wood - Murdoch UniversityG L Hosgood - Murdoch UniversityF Coiacetto - Murdoch University
- Publication Details
- Australian veterinary journal, Vol.103(7), pp.422-429
- Publisher
- John Wiley & Sons Australia, Ltd on behalf of Australian Veterinary Association.
- Number of pages
- 8
- Identifiers
- 991005781725107891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- 1.157 Organ Donation & Transplantation
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- Plant & Animal Science