Journal article
Progressive myopathy with up-regulation of MHC-I associated with statin therapy
Neuromuscular Disorders, Vol.17(2), pp.194-200
2007
Abstract
Statins can cause a necrotizing myopathy and hyperCKaemia which is reversible on cessation of the drug. What is less well known is a phenomenon whereby statins may induce a myopathy, which persists or may progress after stopping the drug. We investigated the muscle pathology in 8 such cases. All had myofibre necrosis but only 3 had an inflammatory infiltrate. In all cases there was diffuse or multifocal up-regulation of MHC-I expression even in non-necrotic fibres. Progressive improvement occurred in 7 cases after commencement of prednisolone and methotrexate, and in one case spontaneously. These observations suggest that statins may initiate an immune-mediated myopathy that persists after withdrawal of the drug and responds to immunosuppressive therapy. The mechanism of this myopathy is uncertain but may involve the induction by statins of an endoplasmic reticulum stress response with associated up-regulation of MHC-I expression and antigen presentation by muscle fibres.
Details
- Title
- Progressive myopathy with up-regulation of MHC-I associated with statin therapy
- Authors/Creators
- M. Needham (Author/Creator)V. Fabian (Author/Creator)W. Knezevicˇ (Author/Creator)P. Panegyres (Author/Creator)P. Zilko (Author/Creator)F.L. Mastaglia (Author/Creator)
- Publication Details
- Neuromuscular Disorders, Vol.17(2), pp.194-200
- Publisher
- Elsevier BV
- Identifiers
- 991005544024307891
- Copyright
- © 2007 Published by Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
31 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior