Progressive white matter injury in preclinical dutch cerebral amyloid angiopathy

Z. Shirzadi; W‐Y.W. Yau; S.A. Schultz; A.P. Schultz; M.R. Scott; M. Goubran; P. Mojiri‐Forooshani; N. Joseph‐Mathurin; K. Kantarci; G. Preboske; M.J.H. Wermer; C. Jack; T. Benzinger; K. Taddei; H.R. Sohrabi; R.A. Sperling; K.A. Johnson; R.J. Bateman; R.N. Martins; S.M. Greenberg; J.P. Chhatwal

doi:10.1002/ana.26429

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Progressive white matter injury in preclinical dutch cerebral amyloid angiopathy

Journal article

Peer reviewed

Progressive white matter injury in preclinical dutch cerebral amyloid angiopathy

Z. Shirzadi, W‐Y.W. Yau, S.A. Schultz, A.P. Schultz, M.R. Scott, M. Goubran, P. Mojiri‐Forooshani, N. Joseph‐Mathurin, K. Kantarci, G. Preboske, …

Annals of Neurology, Vol.92(3), pp.358-363

2022

DOI: https://doi.org/10.1002/ana.26429

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Abstract

Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression.

Details

Title: Progressive white matter injury in preclinical dutch cerebral amyloid angiopathy
Authors/Creators: Z. Shirzadi (Author/Creator) - Massachusetts General Hospital
W‐Y.W. Yau (Author/Creator)
S.A. Schultz (Author/Creator) - Massachusetts General Hospital
A.P. Schultz (Author/Creator) - Massachusetts General Hospital
M.R. Scott (Author/Creator) - Massachusetts General Hospital
M. Goubran (Author/Creator) - Sunnybrook Health Science Centre
P. Mojiri‐Forooshani (Author/Creator) - Sunnybrook Health Science Centre
N. Joseph‐Mathurin (Author/Creator)
K. Kantarci (Author/Creator) - Department of Radiology Mayo clinic Rochester MN United States
G. Preboske (Author/Creator) - Department of Radiology Mayo clinic Rochester MN United States
M.J.H. Wermer (Author/Creator) - Leiden University Medical Center
C. Jack (Author/Creator) - Mayo Clinic
T. Benzinger (Author/Creator) - Mallinckrodt (United States)
K. Taddei (Author/Creator) - Edith Cowan University
H.R. Sohrabi (Author/Creator) - Murdoch University
R.A. Sperling (Author/Creator) - Massachusetts General Hospital
K.A. Johnson (Author/Creator) - Massachusetts General Hospital
R.J. Bateman (Author/Creator) - Mallinckrodt (Ireland)
R.N. Martins (Author/Creator) - Edith Cowan University
S.M. Greenberg (Author/Creator) - Massachusetts General Hospital
J.P. Chhatwal (Author/Creator) - Massachusetts General Hospital
Publication Details: Annals of Neurology, Vol.92(3), pp.358-363
Publisher: Wiley
Identifiers: 991005542876107891
Copyright: © 2022 American Neurological Association.
Murdoch Affiliation: Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior