Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework

S.D. Donofry; C.M. Stillman; J.L. Hanson; M. Sheridan; S. Sun; E.B. Loucks; K.I. Erickson

doi:10.1016/j.neubiorev.2021.09.051

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Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework

Journal article

Open access

Peer reviewed

Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework

S.D. Donofry, C.M. Stillman, J.L. Hanson, M. Sheridan, S. Sun, E.B. Loucks and K.I. Erickson

Neuroscience & Biobehavioral Reviews, Vol.131, pp.688-703

2021

DOI: https://doi.org/10.1016/j.neubiorev.2021.09.051

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Abstract

Adverse childhood experiences such as abuse, neglect, and poverty, profoundly alter neurobehavioral development in a manner that negatively impacts health across the lifespan. Adults who have been exposed to such adversities exhibit premature and more severe age-related declines in brain health. Unfortunately, it remains unclear whether the negative effects of early life adversity (ELA) on brain health can be remediated through intervention in adulthood. Physical activity may represent a low-cost behavioral approach to address the long-term consequences of ELA on brain health. However, there has been limited research examining the impact of physical activity on brain health among adults with a history of ELA. Accordingly, the purpose of this review is to (1) review the influence of ELA on brain health in adulthood and (2) highlight evidence for the role of neurotrophic factors, hypothalamic-adrenal-pituitary axis regulation, inflammatory processes, and epigenetic modifications in mediating the effects of both ELA and physical activity on brain health outcomes in adulthood. We then propose a theoretical framework to guide future research in this area.

Details

Title: Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework
Authors/Creators: S.D. Donofry (Author/Creator) - University of Pittsburgh
C.M. Stillman (Author/Creator) - University of Pittsburgh
J.L. Hanson (Author/Creator) - University of Pittsburgh
M. Sheridan (Author/Creator) - University of North Carolina at Chapel Hill
S. Sun (Author/Creator) - Brown University
E.B. Loucks (Author/Creator) - Brown University
K.I. Erickson (Author/Creator) - University of Pittsburgh
Publication Details: Neuroscience & Biobehavioral Reviews, Vol.131, pp.688-703
Publisher: Elsevier
Identifiers: 991005540866307891
Copyright: © 2021 Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.5 Neuroscience; 1.5.420 Stress and Cortisol
Web Of Science research areas: Behavioral Sciences; Neurosciences
ESI research areas: Neuroscience & Behavior