Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

A. Rauch; D. Nolan; A. Martin; E. McKinnon; C. Almeida; S. Mallal

doi:10.1086/504874

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Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

Journal article

Open access

Peer reviewed

Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

A. Rauch, D. Nolan, A. Martin, E. McKinnon, C. Almeida and S. Mallal

Clinical Infectious Diseases, Vol.43(1), pp.99-102

2006

DOI: https://doi.org/10.1086/504874

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Abstract

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701–negative recipients.

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Title: Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study
Authors/Creators: A. Rauch (Author/Creator) - Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia
D. Nolan (Author/Creator) - Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia
A. Martin (Author/Creator) - Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia
E. McKinnon (Author/Creator) - Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia
C. Almeida (Author/Creator)
S. Mallal (Author/Creator) - Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia
Publication Details: Clinical Infectious Diseases, Vol.43(1), pp.99-102
Publisher: University of Chicago Press
Identifiers: 991005540266707891
Copyright: © 2006 by the Infectious Diseases Society of America
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.265 Dermatology - Skin Allergies; 1.265.1140 Drug Hypersensitivity
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology