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Prospective randomized controlled blinded clinical trial evaluating biomarkers of acute kidney injury following 6% hydroxyethyl starch 130/0.4 or Hartmann's solution in dogs
Journal article   Peer reviewed

Prospective randomized controlled blinded clinical trial evaluating biomarkers of acute kidney injury following 6% hydroxyethyl starch 130/0.4 or Hartmann's solution in dogs

C.J. Boyd, C.R. Sharp, M.A. Claus, A.L. Raisis, G. Hosgood and L. Smart
Journal of Veterinary Emergency and Critical Care, Vol.31(3), pp.306-314
2021
DOI: https://doi.org/10.1111/vec.13056
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Abstract

Objective: To evaluate the effect of 6% hydroxyethyl starch (HES) 130/0.4, compared with a Hartmann's solution control (CRYST), on urine biomarkers of acute kidney injury (AKI) in dogs prescribed a fluid bolus. Design: Randomized, controlled, blinded clinical trial January 2018 to February 2019. Setting: University teaching hospital. Animals: Forty client‐owned dogs. Interventions: Dogs prescribed a fluid bolus were randomized to receive at least 10 mL/kg of HES or CRYST with clinicians and investigators blinded to fluid type. Study fluid was used for further boluses as required in the following 24 hours, to a limit of 40 mL/kg total, after which fluid administration was open‐label. Measurements and Main Results: Urine was collected prior to and 6, 12, and 24 hours after the first study fluid bolus. Urine concentrations of AKI biomarkers: neutrophil gelatinase‐associated lipocalin (NGAL), cystatin C, kidney injury molecule‐1 (KIM), clusterin, and osteopontin were measured using a magnetic bead multiplexed assay. Osmolality‐indexed biomarker concentrations were compared between groups over time with linear mixed‐effects models, with P < 0.05 considered significant. The mean volume of study fluid administered was not significantly different between groups (HES: 23.1 mL/kg, CRYST: 25.9 mL/kg; P = 0.47, t‐test). There were no significant differences between groups in change over time of osmolality‐indexed urine concentrations of NGAL (P = 0.91), cystatin C (P = 0.95), KIM (P = 0.77), clusterin (P = 0.63), or osteopontin (P = 0.91). The maximum Veterinary Acute Kidney Injury (VAKI) score up to 7 days during hospitalization (P = 1.0) and in‐hospital mortality (P = 0.49) were not significantly different between groups, as compared by Fisher's exact test. Conclusions: There were no differences in change over time of urine AKI biomarkers in dogs treated with 10 – 40 mL/kg HES or CRYST over 24 hours. Larger clinical trials with patient‐centered outcomes are required to investigate the safety of HES in dogs.

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Citation topics
1 Clinical & Life Sciences
1.154 Assisted Ventilation
1.154.360 Procalcitonin
Web Of Science research areas
Veterinary Sciences
ESI research areas
Plant & Animal Science
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