Journal article
Prospects for virally vectored immunocontraception in the control of wild house mice (Mus domesticus)
Wildlife Research, Vol.34(7), pp.530-539
2007
Abstract
The wild house mouse (Mus domesticus) is not native to Australia and was introduced from Europe with early settlement. It undergoes periodic population explosions or plagues, which place significant economic and social burdens on agricultural communities. Present control mechanisms rely on improvements to farm hygiene and the use of rodenticides. This review covers over a decade of work on the use of virally vectored immunocontraception (VVIC) as an adjunct method of controlling mouse populations. Two viral vectors, ectromelia virus (ECTV) and murine cytomegalovirus (MCMV) have been tested as potential VVIC vectors: MCMV has been the most widely studied vector because it is endemic to Australia; ECTV less so because its use would have required the introduction of a new pathogen into the Australian environment. Issues such as efficacy, antigen choice, resistance, transmission, species specificity and safety of VVIC are discussed. In broad terms, both vectors when expressing murine zona pellucida 3 (mZP3) induced long-term infertility in most directly inoculated female mice. Whereas innate and acquired resistance to MCMV may be a barrier to VVIC, the most significant barrier appears to be the attenuation seen in MCMV-based vectors. This attenuation is likely to prevent sufficient transmission for broad-scale use. Should this issue be overcome, VVIC has the potential to contribute to the control of house mouse populations in Australia.
Details
- Title
- Prospects for virally vectored immunocontraception in the control of wild house mice (Mus domesticus)
- Authors/Creators
- A.J. Redwood (Author/Creator)L.M. Smith (Author/Creator)M.L. Lloyd (Author/Creator)L.A. Hinds (Author/Creator)C.M. Hardy (Author/Creator)G.R. Shellam (Author/Creator)
- Publication Details
- Wildlife Research, Vol.34(7), pp.530-539
- Publisher
- CSIRO Publishing
- Identifiers
- 991005542444507891
- Copyright
- © 2007 CSIRO
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.711 Cytomegalovirus Infections
- Web Of Science research areas
- Ecology
- Zoology
- ESI research areas
- Plant & Animal Science