Journal article
Protein degradation in bupivacaine-treated muscles
Journal of the Neurological Sciences, Vol.75(3), pp.343-351
1986
Abstract
The time course of protein degradation and the influence of extracellular calcium and the calcium-channel blocker verapamil were investigated by measuring tyrosine release from the isolated rat soleus muscle exposed to the local anaesthetic agent bupivacaine. Degradation rates were reduced during the first 60–90 min and subsequently increased in muscles treated with bupivacaine concentrations of 1.5 mM or higher. When calcium was omitted from the incubation medium the initial reduction in degradation was greater and the subsequent increase was reduced or prevented. Overall, verapamil (10−5M or 10−6M) did not significantly alter the degree or time-course of protein degradation.
Details
- Title
- Protein degradation in bupivacaine-treated muscles
- Authors/Creators
- J.H. Steer (Author/Creator) - The University of Western AustraliaF.L. Mastaglia (Author/Creator) - The University of Western Australia
- Publication Details
- Journal of the Neurological Sciences, Vol.75(3), pp.343-351
- Publisher
- Elsevier BV
- Identifiers
- 991005544649607891
- Copyright
- © 1986 Published by Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.249 Digestive System Disorders
- 1.249.1227 Glutamine Metabolism
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior