Journal article
Proteomic analysis of Giardia: Studies from the pre- and post-genomic era
Experimental Parasitology, Vol.124(1), pp.26-30
2010
Abstract
The proteome of Giardia duodenalis has been under study for the last 25 years and has lead to the discovery of valuable information on the biology and variation of the parasite. Proteomic techniques, mainly SDS-PAGE and 2D-PAGE, have been used to investigate protein variation, cellular structure and host parasite interactions. This has allowed for the identification of assemblage and host specific proteins, structural proteins, proteins released by trophozoites upon exposure to host cell monolayers and immunoreactive proteins. These data are important in understanding the pathogenesis of G. duodenalis infections, as well as highlighting potential drug and vaccine targets. There is, however, a large amount of future work needed to fully understand the proteome of this parasite.
Details
- Title
- Proteomic analysis of Giardia: Studies from the pre- and post-genomic era
- Authors/Creators
- R.F.L. Steuart (Author/Creator) - Murdoch University
- Publication Details
- Experimental Parasitology, Vol.124(1), pp.26-30
- Publisher
- Academic Press
- Identifiers
- 991005541437807891
- Copyright
- © 2009 Elsevier Inc.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.246 Diarrheal Diseases
- 1.246.985 Cryptosporidium
- Web Of Science research areas
- Parasitology
- ESI research areas
- Microbiology